CARM1 - coactivator associated arginine methyltransferase 1 Gene

Also Known as PRMT4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10498

About CARM1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,871,553-10,923,075 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 20.7), placenta (RPKM 17.2) and 25 other tissues.

Summary

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and Other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with Other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

CARM1 Products (5)

mRNA Protein Name
NM_199141.2 NP_954592.1 histone-arginine methyltransferase CARM1 isoform 1
XM_047438058.1 XP_047294014.1 histone-arginine methyltransferase CARM1 isoform X1
NM_001370088.1 NP_001357017.1 histone-arginine methyltransferase CARM1 isoform 2
NM_001370089.1 NP_001357018.1 histone-arginine methyltransferase CARM1 isoform 3
XM_011527638.3 XP_011525940.1 histone-arginine methyltransferase CARM1 isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
15471871 GOA
enables histone H3R17 methyltransferase activity IDA
IDA: Inferred from direct assay
15471871 GOA
enables histone H3R2 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
17898714 GOA
enables histone arginine N-methyltransferase activity IDA
IDA: Inferred from direct assay
23980157 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16938873 GOA
enables protein-arginine N-methyltransferase activity IDA
IDA: Inferred from direct assay
18495660 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
15471871 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of epithelial cell apoptotic process IDA
IDA: Inferred from direct assay
34480022 GOA
involved in positive regulation of transcription by RNA polymerase I IDA
IDA: Inferred from direct assay
15471871 GOA
involved in replication fork reversal IDA
IDA: Inferred from direct assay
33412112 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15221992 GOA
is active in nuclear replication fork IDA
IDA: Inferred from direct assay
33412112 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15221992 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARM1 Protein Structure

CARM1

CARM1: Coactivator-associated arginine methyltransferase 1 N terminal (27 - 139)

PRMT5

PRMT5: PRMT5 arginine-N-methyltransferase (184 - 435)

  • 0
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  • 200
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  • 400
  • 500
  • 608 a.a.
Protein Preferred Names Protein Names

histone-arginine methyltransferase CARM1

  • protein arginine N-methyltransferase 4

CARM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
CARM1 Q86X55 a0a1u8qn96_yerpe Yersinia pestis A0A1U8QN96
Y2H Array
21911467
Intra
CARM1 Q86X55 SMARCC1 Homo sapiens Q92922
Anti Tag CoIP
24434208
Intra
CARM1 Q86X55 NUDT21 Homo sapiens O43809
Anti Tag CoIP
23455924
Intra
CARM1 Q86X55 DNAJA3 Homo sapiens Q96EY1
Y2H
23455924
Intra
CARM1 Q86X55 NCOA3 Homo sapiens Q9Y6Q9
Anti Bait CoIP
16938873
Intra
CARM1 Q86X55 QKI Homo sapiens Q96PU8
Y2H
23455924
Intra
CARM1 Q86X55 CEBPB Homo sapiens P17676
Anti Bait CoIP
20111005
Intra
CARM1 Q86X55 CEBPB Homo sapiens P17676
Anti Tag CoIP
20111005
Cross
CARM1 Q86X55 CEBPB Gallus gallus Q05826
Anti Tag CoIP
20111005
Cross: Cross-species interaction Intra: Intraspecies interaction

CARM1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80583 CARM1 Antibody (YA812) WB, IP Human, Mouse
HY-P80583A CARM1 Antibody (YA812)(PBS only) WB, IP Human, Mouse
HY-P84662 CARM1 Antibody (YA4359) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat, Rabbit, Monkey
HY-P84662A CARM1 Antibody (YA4359)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat, Rabbit, Monkey
HY-P85335 CARM1 Antibody (YA5027) WB, IHC-P, IP Human, Mouse, Rat
HY-P85492 CARM1 Antibody (YA5184) WB, IP Human, Mouse

Related Diseases

Diseases Alias
Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

  • Severe Congenital Encephalopathy Due To Mecp2 Mutation

  • Severe Neonatal-Onset Encephalopathy With Microcephaly

  • Encephalopathy, Neonatal Severe

  • Neonatal Severe Encephalopathy Due To Mecp2 Mutations

  • Mecp2-Related Severe Neonatal Encephalopathy

  • Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy

  • Severe Neonatal Encephalopathy Due To Mecp2 Mutations

  • ENS-MECP2

  • Encephalopathy, Neonatal, Severe
Muscular Atrophy

  • Muscle Wasting

  • Amyotrophia

  • Wasting - Muscle

  • Skeletal Muscle Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114965 TP-064 Inhibitor 99.29% Unkown
HY-111109 EZM 2302 Inhibitor 99.51% Unkown
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% Unkown
HY-100565 SGC2085 Inhibitor 99.46% Unkown
HY-12759 CARM1-IN-1 Inhibitor 95.0% Unkown
HY-21999 tert-Butyl 6-aminocaproate 99.96% Unkown
HY-156152A PROTAC CARM1 degrader-1 hydrochloride Degrader 99.94% Unkown
HY-12759A CARM1-IN-1 hydrochloride Inhibitor 95.17% Unkown
HY-15214 CARM1-IN-3 Inhibitor 98.90% Unkown
HY-15214A CARM1-IN-3 dihydrochloride Inhibitor 98.77% Unkown
HY-157388 CARM1/HDAC2-IN-1 Inhibitor 95.17% Unkown
HY-163561 CARM1-IN-6 99.59% Unkown
HY-163561A CARM1-IN-6 dihydrochloride Inhibitor 98.44% Unkown
HY-RS01926 CARM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100855 DC_C66 Inhibitor / Unkown
HY-100565A SGC2085 hydrochloride Inhibitor / Unkown
HY-110137A Furamidine Inhibitor / Unkown
HY-114510 PRMT/HKMT-IN-1 / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-136809 PRMT6-IN-2 Inhibitor / Unkown
HY-156152 PROTAC CARM1 degrader-1 Inhibitor / Unkown
HY-156153 PROTAC CARM1 degrader-2 Inhibitor / Unkown
HY-158157 ZL-28-6 Inhibitor / Unkown
HY-158158 CARM1-IN-5 Inhibitor / Unkown
HY-161334 CARM1-IN-4 / Unkown
HY-172368 PROTAC CARM1/IKZF3 degrader-1 / Unkown
HY-172369 CARM1/IKZF3 ligand 1 Inhibitor / Unkown
HY-181413 PROTAC EZH2 Degrader-44 / Unkown
HY-183653 AK442 Inhibitor / Unkown
HY-RS01927 Carm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01928 Carm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114206 SKI-73 / Unkown
HY-117927 EPZ0025654 Inhibitor / Unkown
HY-172370 Thalidomide-NH-C4-Boc / Unkown
HY-W013500 (1-Nitroethene-1,2-diyl)dibenzene Inhibitor 99.05% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CARM1 VGNC VGNC:60369
Bos taurus CARM1 VGNC VGNC:26767
Macaca mulatta CARM1 VGNC VGNC:70612
Canis familiaris CARM1 VGNC VGNC:38721
Mus musculus CARM1 MGD MGI:1913208
Rattus norvegicus CARM1 RGD RGD:1305879
Others CARM1 NCBI