CARM1 - coactivator associated arginine methyltransferase 1 Gene

Homo sapiens

Also known as PRMT4

Gene ID: 10498 | Gene type: protein coding

About CARM1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,871,553-10,923,075 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 20.7), placenta (RPKM 17.2) and 25 other tissues.

Summary

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded Enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The Enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The Enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

CARM1 Products(5)

mRNA	Protein	Name
NM_199141.2	NP_954592.1	histone-arginine methyltransferase CARM1 isoform 1
XM_047438058.1	XP_047294014.1	histone-arginine methyltransferase CARM1 isoform X1
NM_001370088.1	NP_001357017.1	histone-arginine methyltransferase CARM1 isoform 2
NM_001370089.1	NP_001357018.1	histone-arginine methyltransferase CARM1 isoform 3
XM_011527638.3	XP_011525940.1	histone-arginine methyltransferase CARM1 isoform X2

CARM1 Protein Structure

CARM1

PRMT5

0
100
200
300
400
500
608 a.a.

Protein Preferred Names

Protein Names

histone-arginine methyltransferase CARM1

protein arginine N-methyltransferase 4

Related Diseases

Diseases

Alias

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111109	EZM 2302	Inhibitor	99.59%	Unkown
HY-114965	TP-064	Inhibitor	98.35%	Unkown
HY-100565	SGC2085	Inhibitor	99.45%	Unkown
HY-12759	CARM1-IN-1	Inhibitor	≥95.0%	Unkown
HY-110137	Furamidine dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-15214A	CARM1-IN-3 dihydrochloride	Inhibitor	98.77%	Unkown
HY-12759A	CARM1-IN-1 hydrochloride	Inhibitor	95.16%	Unkown
HY-15214	CARM1-IN-3	Inhibitor	98.90%	Unkown
HY-157388	CARM1/HDAC2-IN-1	Inhibitor	/	Unkown
HY-100855	DC_C66	Inhibitor	/	Unkown
HY-100565A	SGC2085 hydrochloride	Inhibitor	/	Unkown
HY-110137A	Furamidine	Inhibitor	/	Unkown
HY-156152	CARM1 degrader-1	Inhibitor	/	Unkown
HY-156153	CARM1 degrader-2	Inhibitor	/	Unkown
HY-158157	ZL-28-6	Inhibitor	/	Unkown
HY-158158	CARM1-IN-5	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4		/	Unkown
HY-RS01926	CARM1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01927	Carm1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01928	Carm1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CARM1	VGNC	VGNC:60369
Bos taurus	CARM1	VGNC	VGNC:26767
Macaca mulatta	CARM1	VGNC	VGNC:70612
Canis familiaris	CARM1	VGNC	VGNC:38721
Mus musculus	CARM1	MGD	MGI:1913208
Rattus norvegicus	CARM1	RGD	RGD:1305879

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