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DNAJA3 - DnaJ heat shock protein family (Hsp40) member A3 Gene

Also Known as TID1; HCA57; hTID-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9093

About DNAJA3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,425,868-4,456,775 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 282 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 19.3), kidney (RPKM 17.5) and 25 other tissues.

Summary

This gene encodes a member of the DNAJ/HSP40 protein family. DNAJ/HSP40 proteins stimulate the ATPase activity of HSP70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

DNAJA3 Products (3)

mRNA	Protein	Name
NM_001135110.3	NP_001128582.1	dnaJ homolog subfamily A member 3, mitochondrial isoform 2
NM_001286516.2	NP_001273445.1	dnaJ homolog subfamily A member 3, mitochondrial isoform 3
NM_005147.6	NP_005138.3	dnaJ homolog subfamily A member 3, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	21106534	GOA
enables IkappaB kinase complex binding	IDA IDA: Inferred from direct assay	15601829	GOA
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	15601829	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16531398	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10411904	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11679576	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15601829	GOA
enables type II interferon receptor binding	IDA IDA: Inferred from direct assay	11679576	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	10411904	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11927590	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10411904	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11927590	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11719219	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	10411904	GOA
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	15601829	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21106534	GOA
involved in negative regulation of type II interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	11679576	GOA
involved in neuromuscular junction development	IDA IDA: Inferred from direct assay	19038220	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10411904	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	15520177	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	16531398	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	11927590	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	11679576	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with actin filament	IDA IDA: Inferred from direct assay	17588722	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11679576	GOA
located in cytosol	IMP IMP: Inferred from mutant phenotype	16531398	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	10411904	GOA
located in mitochondrial nucleoid	IDA IDA: Inferred from direct assay	16531398	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20053669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11679576	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJA3 Protein Structure

DnaJ

DnaJ_CXXCXGXG

DnaJ_C

0
100
200
300
400
480 a.a.

Protein Preferred Names	Protein Names
dnaJ homolog subfamily A member 3, mitochondrial	DnaJ (Hsp40) homolog, subfamily A, member 3

DNAJA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DNAJA3	Q96EY1	STAT5B	Homo sapiens	P51692	Anti Bait CoIP	21106534
Cross	DNAJA3	Q96EY1	Ptch1	Mus musculus	Q61115	Anti Bait CoIP	17230190
Cross	DNAJA3	Q96EY1	Ptch1	Mus musculus	Q61115	Anti Tag CoIP	17230190
Intra	DNAJA3	Q96EY1	CARM1	Homo sapiens	Q86X55	Anti Tag CoIP	23455924
Intra	DNAJA3	Q96EY1	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	DNAJA3	Q96EY1	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	DNAJA3	Q96EY1	HTT	Homo sapiens	P42858	Y2H	17500595
Cross	DNAJA3	Q96EY1	Stat5b	Mus musculus	P42232	Y2H	21106534
Intra	DNAJA3	Q96EY1	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	DNAJA3	Q96EY1	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	DNAJA3	Q96EY1	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	DNAJA3	Q96EY1	KDM1A	Homo sapiens	O60341	Y2H	23455924
Intra	DNAJA3	Q96EY1	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23455924
Intra	DNAJA3	Q96EY1	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924
Intra	DNAJA3	Q96EY1	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924
Intra	DNAJA3	Q96EY1	ATXN1	Homo sapiens	P54253	Y2H	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Myasthenic Syndrome, Congenital, 12	Congenital Myasthenic Syndrome 12 CMS12 Myasthenic Syndrome, Congenital, With Tubular Aggregates 1 Cmsta1 Myasthenia, Congenital, 12, With Tubular Aggregates Congenital Myasthenia 12 With Tubular Aggregates Limb-Girdle Myasthenia With Tubular Aggregates Myasthenia, Congenital, With Tubular Aggregates 1 Myasthenic Syndrome, Congenital, With Tubular Aggregates, 1
Alternating Esotropia
Codas Syndrome	Cerebral, Ocular, Dental, Auricular, And Skeletal Anomalies Syndrome Cerebral, Ocular, Dental, Auricular, And Skeletal Syndrome Cerebro-Oculo-Dento-Auriculo-Skeletal Syndrome Cerebrooculodentoauriculoskeletal Syndrome CODASS Cerebral, Ocular, Dental, Auricular, Skeletal Syndrome
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Congenital Myasthenic Syndrome	Congenital Myasthenia Congenital Myasthenic Syndromes Cms Myasthenic Syndromes, Congenital Myasthenic Syndromes Congenital Myasthenic Syndrome, Congenital Congenital Myasthenic Syndrome Ib Congenital And Developmental Myasthenia Developmental Myasthenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS03859	DNAJA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DNAJA3	VGNC	VGNC:99506
Felis catus	DNAJA3	VGNC	VGNC:80564
Mus musculus	DNAJA3	MGD	MGI:1933786
Rattus norvegicus	DNAJA3	RGD	RGD:1306527
Canis familiaris	DNAJA3	VGNC	VGNC:49081
Others	DNAJA3	NCBI