SGC2085 hydrochloride
Based on 1 publication(s) in Google Scholar
SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1821908-49-9
- Formel: C19H25ClN2O2
- Molecular Weight:348.87
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
-
Help & FAQs
-
HY-19715
SGC707PRMT3 Inhibitor -
HY-101564
OnametostatPRMT5 Inhibitor -
HY-19615
MS023Type I PRMT Inhibitor -
HY-12220
MM-102WDR5/MLL Inhibitor -
HY-12727
EPZ015666PRMT5 Inhibitor -
HY-13808
UNC 0631G9a Inhibitor -
HY-128717A
GSK3368715 dihydrochloridePRMT Inhibitor -
HY-13808R
UNC 0631 (Standard)Analytical Standard -
HY-100235
GSK591PRMT5 Inhibitor -
HY-12186
3-Deazaneplanocin A hydrochlorideEZH2 Inhibitor -
HY-18962
AMI-1PRMTs Inhibitor -
HY-13803
TazemetostatEZH2 Inhibitor
Publications Citing Use of MedChemExpress (MCE) SGC2085 hydrochloride
MoreAlle Histone Methyltransferase Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PRMT6 5.2 μM (IC50) |
In Vitro
SGC2085 hydrochloride (1 μM, 10 μM, 50 μM; 48 h) is fully selective for 21 human protein methyltransferases[1].
SGC2085 hydrochloride (10 μM; 48 h) exhibits low cell permeability and no cell activity in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 1821908-49-9
-
Molecular Weight 348.87
-
Formel C19H25ClN2O2
-
SMILES
[H]Cl.CC1=CC(OC2=CC=C(CNC([C@@H](N)C)=O)C=C2C)=CC(C)=C1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Acta Pharmacol Sin
2022 Feb;43(2):457-469. PMID: 33850273
Protokoll
Cell Assay[1]
SGC2085 is dissolved in DMSO and diluted with appropriate medium before use. HEK293 cells are grown in 12-well plates in DMEM supplemented with 10% FBS, penicillin (100 U/mL), and streptomycin (100 μg/mL). Thirty percent confluent cells are treated with inhibitors or DMSO. After 48 h, media are removed and cells are lysed in 100 μL of total lysis buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, 10 mM MgCl2, 0.5% Triton X-100, 12.5 U/mL benzonase), complete EDTA-free protease inhibitor cocktail. After 3 min incubation at room temperature, SDS is added to 1% final concentration. Lysates are run on SDS-PAGE, and immunoblotting is done as outlined below to determine the levels of unmethylated and methylated BAF155[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Reinheit & Dokumentation
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SGC2085 hydrochloride Related Classifications
HY-100565A Related Classifications
Powered by Bioz