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NUDT21 - nudix hydrolase 21 Gene

Also Known as CPSF5; CFIM25

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11051

About NUDT21

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,429,133-56,451,332 (from NCBI)

This gene has 7 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in brain (RPKM 30.7), ovary (RPKM 29.1) and 25 other tissues.

Summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of Other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]

NUDT21 Products (1)

mRNA	Protein	Name
NM_007006.3	NP_008937.1	cleavage and polyadenylation specificity factor subunit 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to RNA binding	IDA IDA: Inferred from direct assay	8626397	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17172643	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	20695905	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	20479262	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	21295486	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11716503	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20479262	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	IDA IDA: Inferred from direct assay	29276085	GOA
involved in mRNA 3'-end processing	IDA IDA: Inferred from direct assay	15937220	GOA
involved in mRNA alternative polyadenylation	IMP IMP: Inferred from mutant phenotype	17098938	GOA
involved in mRNA processing	IDA IDA: Inferred from direct assay	8626397	GOA
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	23187700	GOA
involved in protein tetramerization	IDA IDA: Inferred from direct assay	21295486	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19864460	GOA
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: Inferred from direct assay	23187700	GOA
part of mRNA cleavage factor complex	IDA IDA: Inferred from direct assay	20695905	GOA
part of mRNA cleavage factor complex	IPI IPI: Inferred from physical interaction	20695905	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19864460	GOA
located in paraspeckles	IDA IDA: Inferred from direct assay	15169763	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT21 Protein Structure

NUDIX_2

0
100
200
227 a.a.

Protein Preferred Names	Protein Names
cleavage and polyadenylation specificity factor subunit 5	CPSF 25 kDa subunit

NUDT21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630-1	X-Ray Diffraction	21295486
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630-1	Ion Exchange Chrom	21295486
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630-1	Pull Down	21295486
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630-1	GMS	21295486
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630-2	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630-2	Validated Y2H	32296183
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630-2	Y2H Array	32296183
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630-2	Anti Tag CoIP	26496610
Intra	NUDT21	O43809	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	NUDT21	O43809	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	NUDT21	O43809	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	NUDT21	O43809	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	NUDT21	O43809	CPSF7	Homo sapiens	Q8N684-3	Validated Y2H	32296183
Intra	NUDT21	O43809	CPSF7	Homo sapiens	Q8N684-3	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	CPSF7	Homo sapiens	Q8N684-3	Y2H Array	32296183
Intra	NUDT21	O43809	SPAG8	Homo sapiens	Q99932-2	Y2H Array	32296183
Intra	NUDT21	O43809	SPAG8	Homo sapiens	Q99932-2	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	NUDT21	O43809	PSPC1	Homo sapiens	Q8WXF1-2	Validated Y2H	32296183
Intra	NUDT21	O43809	S100PBP	Homo sapiens	Q96BU1	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	S100PBP	Homo sapiens	Q96BU1	Validated Y2H	32296183
Intra	NUDT21	O43809	S100PBP	Homo sapiens	Q96BU1	Y2H Array	32296183
Intra	NUDT21	O43809	CARM1	Homo sapiens	Q86X55	Y2H	23455924
Intra	NUDT21	O43809	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	KRT75	Homo sapiens	O95678	Validated Y2H	32296183
Intra	NUDT21	O43809	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	NUDT21	O43809	MYL6	Homo sapiens	P60660	Y2H Array	31515488
Intra	NUDT21	O43809	MYL6	Homo sapiens	P60660	Validated Y2H	32296183
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630	Pull Down	22960638
Intra	NUDT21	O43809	NUDT21	Homo sapiens	O43809	X-Ray Diffraction	20479262
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630	Anti Bait CoIP	22960638
Intra	NUDT21	O43809	NUDT21	Homo sapiens	O43809	Validated Y2H	32296183
Intra	NUDT21	O43809	NUDT21	Homo sapiens	O43809	Y2H Array	25416956
Intra	NUDT21	O43809	CPSF6	Homo sapiens	Q16630	Y2H Pooling	16189514
Intra	NUDT21	O43809	NUDT21	Homo sapiens	O43809	Y2H Array	32296183
Intra	NUDT21	O43809	NUDT21	Homo sapiens	O43809	Y2H Pooling	16189514
Intra	NUDT21	O43809	NUDT21	Homo sapiens	O43809	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	NUDT21	O43809	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	NUDT21	O43809	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	NUDT21	O43809	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	NUDT21	O43809	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	NUDT21	O43809	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	NUDT21	O43809	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
Intra	NUDT21	O43809	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	NUDT21	O43809	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	NUDT21	O43809	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	NUDT21	O43809	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	NUDT21	O43809	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	NUDT21	O43809	TRIM23	Homo sapiens	P36406	Validated Y2H	32296183
Intra	NUDT21	O43809	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	NUDT21	O43809	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	NUDT21	O43809	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	NUDT21	O43809	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	NUDT21	O43809	CPSF7	Homo sapiens	Q8N684	Y2H Pooling	16189514
Intra	NUDT21	O43809	CPSF7	Homo sapiens	Q8N684	Validated Y2H	25416956
Intra	NUDT21	O43809	CPSF7	Homo sapiens	Q8N684	Y2H Prey Pooling	25416956
Intra	NUDT21	O43809	ATXN1	Homo sapiens	P54253	Y2H Array	16713569
Intra	NUDT21	O43809	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	NUDT21	O43809	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	NUDT21	O43809	ATXN1	Homo sapiens	P54253	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09669	NUDT21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NUDT21	VGNC	VGNC:32336
Rattus norvegicus	NUDT21	RGD	RGD:1305766
Macaca mulatta	NUDT21	VGNC	VGNC:99533
Mus musculus	NUDT21	MGD	MGI:1915469
Felis catus	NUDT21	VGNC	VGNC:97541
Others	NUDT21	NCBI