CPSF6 - cleavage and polyadenylation specific factor 6 Gene

Also Known as CFIM; CFIM68; CFIM72; HPBRII-4; HPBRII-7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11052

About CPSF6

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,239,569-69,274,358 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.3), lymph node (RPKM 15.0) and 25 other tissues.

Summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of Other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]

CPSF6 Products (2)

mRNA Protein Name
NM_001300947.2 NP_001287876.1 cleavage and polyadenylation specificity factor subunit 6 isoform 2
NM_007007.3 NP_008938.2 cleavage and polyadenylation specificity factor subunit 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to RNA binding IDA
IDA: Inferred from direct assay
15169763 GOA
enables exon-exon junction complex binding IDA
IDA: Inferred from direct assay
19864460 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
21295486 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14561889 GOA
enables ribosomal large subunit binding IDA
IDA: Inferred from direct assay
19864460 GOA
Biological Process GO Annotation Evidence References Source
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IDA
IDA: Inferred from direct assay
29276085 GOA
involved in mRNA 3'-end processing IDA
IDA: Inferred from direct assay
20695905 GOA
involved in mRNA alternative polyadenylation IMP
IMP: Inferred from mutant phenotype
20695905 GOA
involved in mRNA processing IDA
IDA: Inferred from direct assay
14690600 GOA
involved in positive regulation of RNA export from nucleus IMP
IMP: Inferred from mutant phenotype
19864460 GOA
involved in protein heterotetramerization IDA
IDA: Inferred from direct assay
23187700 GOA
involved in protein tetramerization IDA
IDA: Inferred from direct assay
20695905 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19864460 GOA
located in interchromatin granule IDA
IDA: Inferred from direct assay
17267687 GOA
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: Inferred from direct assay
23187700 GOA
part of mRNA cleavage factor complex IDA
IDA: Inferred from direct assay
9659921 GOA
part of mRNA cleavage factor complex IPI
IPI: Inferred from physical interaction
21295486 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
17267687 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
17267687 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19864460 GOA
located in paraspeckles IDA
IDA: Inferred from direct assay
9659921 GOA
located in perichromatin fibrils IDA
IDA: Inferred from direct assay
17267687 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
18809582 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPSF6 Protein Structure

(83 - 152)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 551 a.a.
Protein Preferred Names Protein Names

cleavage and polyadenylation specificity factor subunit 6

  • CPSF 68 kDa subunit

CPSF6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CPSF6 Q16630 TOLLIP Homo sapiens Q6FIE9
Y2H Prey Pooling
25416956
Intra
CPSF6 Q16630 PPIL1 Homo sapiens Q9Y3C6
Y2H Array
25416956
Intra
CPSF6 Q16630 PPIL1 Homo sapiens Q9Y3C6
Anti Tag CoIP
35271311
Intra
CPSF6 Q16630 NUDT21 Homo sapiens O43809
Anti Tag CoIP
33961781
Intra
CPSF6 Q16630 NUDT21 Homo sapiens O43809
Pull Down
22960638
Intra
CPSF6 Q16630 NUDT21 Homo sapiens O43809
Anti Bait CoIP
22960638
Intra
CPSF6 Q16630 NUDT21 Homo sapiens O43809
Pull Down
35177536
Intra
CPSF6 Q16630 NUDT21 Homo sapiens O43809
Anti Tag CoIP
35271311
Intra
CPSF6 Q16630 PLSCR1 Homo sapiens O15162
Pull Down
16189514
Intra
CPSF6 Q16630 WWP1 Homo sapiens Q9H0M0
Anti Tag CoIP
33961781
Intra
CPSF6 Q16630 WWP1 Homo sapiens Q9H0M0
Y2H Pooling
16189514
Intra
CPSF6 Q16630 WWP1 Homo sapiens Q9H0M0
Y2H Pooling
19447967
Intra
CPSF6 Q16630 WWP1 Homo sapiens Q9H0M0
Anti Tag CoIP
35271311
Intra
CPSF6 Q16630 ARMC7 Homo sapiens Q9H6L4
Y2H Pooling
16189514
Intra
CPSF6 Q16630 WWP2 Homo sapiens O00308
Anti Tag CoIP
35271311
Intra
CPSF6 Q16630 WWP2 Homo sapiens O00308
Y2H Pooling
16189514
Intra
CPSF6 Q16630 OTUB2 Homo sapiens Q96DC9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

CPSF6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82809 CPSF6 Antibody (YA2554) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat
HY-P82809A CPSF6 Antibody (YA2554)(PBS only) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Carnitine-Acylcarnitine Translocase Deficiency

  • Cact Deficiency

  • Carnitine Acylcarnitine Translocase Deficiency

  • CACTD

  • Carnitine-Acylcarnitine Carrier Deficiency
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120072 PF-3450074 Inhibitor 98.89% Unkown
HY-RS03120 CPSF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21539 Cpsf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28057 Cpsf6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CPSF6 VGNC VGNC:61144
Mus musculus CPSF6 MGD MGI:1913948
Macaca mulatta CPSF6 VGNC VGNC:71401
Bos taurus CPSF6 VGNC VGNC:27674
Canis familiaris CPSF6 VGNC VGNC:39577
Rattus norvegicus CPSF6 RGD RGD:1304640
Others CPSF6 NCBI