MYL6 - myosin light chain 6 Gene

Also Known as LC17; ESMLC; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM; LC17-GI; LC17-NM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4637

About MYL6

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,158,359-56,161,579 (from NCBI)

This gene has 21 transcripts (splice variants), 295 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 771.0), endometrium (RPKM 608.0) and 25 other tissues.

Summary

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a Myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

MYL6 Products (2)

mRNA Protein Name
NM_021019.5 NP_066299.2 myosin light polypeptide 6 isoform 1
NM_079423.4 NP_524147.2 myosin light polypeptide 6 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables structural constituent of muscle IDA
IDA: Inferred from direct assay
16953301 GOA
Cellular Component GO Annotation Evidence References Source
located in brush border IDA
IDA: Inferred from direct assay
22114352 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYL6 Protein Structure

EF-hand_6

EF-hand_6: EF-hand domain (11 - 40)

  • 0
  • 100
  • 151 a.a.
Protein Preferred Names Protein Names

myosin light polypeptide 6

  • 17 kDa myosin light chain

MYL6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYL6 P60660 NUDT21 Homo sapiens O43809
Y2H Pooling
16189514
Intra
MYL6 P60660 NUDT21 Homo sapiens O43809
Y2H Array
32296183
Intra
MYL6 P60660 NUDT21 Homo sapiens O43809
Y2H Prey Pooling
32296183
Intra
MYL6 P60660 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
MYL6 P60660 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
MYL6 P60660 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
MYL6 P60660 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
MYL6 P60660 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
MYL6 P60660 ADAMTS12 Homo sapiens P58397
Y2H Array
25416956
Intra
MYL6 P60660 ADAMTS12 Homo sapiens P58397
Y2H Prey Pooling
25416956
Intra
MYL6 P60660 GAS2L3 Homo sapiens Q86XJ1
Y2H Prey Pooling
32296183
Intra
MYL6 P60660 GAS2L3 Homo sapiens Q86XJ1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

MYL6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85656 Myosin Heavy Chain Antibody (YA5348) ICC/IF Human, Mouse, Rat, FruitFly, Nematode

Related Diseases

Diseases Alias
Noonan Syndrome 2

  • NS2

  • Noonan Syndrome, Autosomal Recessive

  • Noonan Syndrome 2, Autosomal Recessive

  • Noonan Syndrome, Type 2
Adrenal Gland Pheochromocytoma

  • Pheochromocytoma
Noonan Syndrome 1

  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08918 MYL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08919 MYL6B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22247 Myl6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MYL6 VGNC VGNC:68386
Rattus norvegicus MYL6 RGD RGD:1589019
Mus musculus MYL6 MGD MGI:109318
Bos taurus MYL6 VGNC VGNC:50223
Others MYL6 NCBI