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GAS2L3 - growth arrest specific 2 like 3 Gene

Also Known as G2L3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283431

About GAS2L3

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:100,573,684-100,628,288 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and 36 paralogues. Broad expression in gall bladder (RPKM 2.2), colon (RPKM 1.8) and 23 other tissues.

Summary

Enables actin binding activity and microtubule binding activity. Involved in actin Cytoskeleton organization and microtubule Cytoskeleton organization. Located in actin Cytoskeleton and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

GAS2L3 Products (4)

mRNA	Protein	Name
NM_001303130.2	NP_001290059.1	GAS2-like protein 3 isoform a
NM_001303131.2	NP_001290060.1	GAS2-like protein 3 isoform b
NM_001363672.2	NP_001350601.1	GAS2-like protein 3 isoform a
NM_174942.3	NP_777602.1	GAS2-like protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IDA IDA: Inferred from direct assay	21561867	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	21561867	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24571573	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	21561867	GOA
involved in microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	21561867	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	21561867	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	21561867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAS2L3 Protein Structure

GAS2

0
200
400
600
694 a.a.

Protein Preferred Names	Protein Names
GAS2-like protein 3	growth arrest-specific protein 2-like 3

GAS2L3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GAS2L3	Q86XJ1	MYL6	Homo sapiens	P60660	Y2H Array	32296183
Intra	GAS2L3	Q86XJ1	BIRC5	Homo sapiens	O15392	Pull Down	24571573
Intra	GAS2L3	Q86XJ1	BIRC5	Homo sapiens	O15392	Anti Bait CoIP	24571573
Intra	GAS2L3	Q86XJ1	AURKB	Homo sapiens	Q96GD4	Pull Down	24571573
Intra	GAS2L3	Q86XJ1	AURKB	Homo sapiens	Q96GD4	IF	24571573
Intra	GAS2L3	Q86XJ1	AURKB	Homo sapiens	Q96GD4	Anti Bait CoIP	24571573
Intra	GAS2L3	Q86XJ1	TSR2	Homo sapiens	Q969E8	Validated Y2H	32296183
Intra	GAS2L3	Q86XJ1	CDCA8	Homo sapiens	Q53HL2	Pull Down	24571573

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Anemia, Congenital Dyserythropoietic, Type Iiia	Congenital Dyserythropoietic Anemia, Type Iii Cdan3 Congenital Dyserythropoietic Anemia Type Iii Cda Iii Congenital Dyserythropoietic Anemia Type 3 CDAN3A Dyserythropoietic Anemia, Congenital, Type Iiia Cda, Type Iiia Anemia, Congenital Dyserythropoietic, Type Iii Anemia With Multinucleated Erythroblasts Cda Type 3 Cda Type Iii Dyserythropoietic Anemia, Congenital Type 3 Cda, Type Iii Erythroreticulosis, Hereditary Benign Anaemia With Multinucleated Erythroblasts Congenital Dyserythropoietic Anaemia Type 3 Congenital Dyserythropoietic Anaemia Type Iii Hereditary Benign Erythroreticulosis Anemia, Congenital Dyserythropoietic, 3a Anemia With Multinucleated Erythroblasts Erythroreticulosis, Hereditary Benign

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05284	GAS2L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GAS2L3	VGNC	VGNC:72794
Felis catus	GAS2L3	VGNC	VGNC:62468
Rattus norvegicus	GAS2L3	RGD	RGD:1594151
Bos taurus	GAS2L3	VGNC	VGNC:29260
Mus musculus	GAS2L3	MGD	MGI:1918780
Canis familiaris	GAS2L3	VGNC	VGNC:41117
Others	GAS2L3	NCBI