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CDCA8 - cell division cycle associated 8 Gene

Also Known as BOR; DasraB; MESRGP; BOREALIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55143

About CDCA8

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,692,516-37,709,719 (from NCBI)

This gene has 2 transcripts (splice variants) and 210 orthologues. Biased expression in testis (RPKM 14.3), bone marrow (RPKM 12.4) and 13 other tissues.

Summary

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of Mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

CDCA8 Products (2)

mRNA	Protein	Name
NM_001256875.2	NP_001243804.1	borealin
NM_018101.4	NP_060571.1	borealin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16239925	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	15260989	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	15260989	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of chromosome passenger complex	IPI IPI: Inferred from physical interaction	15260989	GOA
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	15260989	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	9859993	GOA
located in midbody	IDA IDA: Inferred from direct assay	22724069	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	16239925	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDCA8 Protein Structure

Nbl1_Borealin_N

Borealin

0
100
200
280 a.a.

Protein Preferred Names	Protein Names
borealin	Dasra B

CDCA8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDCA8	Q53HL2	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	CDCA8	Q53HL2	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	CDCA8	Q53HL2	SPANXN2	Homo sapiens	Q5MJ10	Validated Y2H	32296183
Intra	CDCA8	Q53HL2	FBXO17	Homo sapiens	Q96EF6	Validated Y2H	32296183
Intra	CDCA8	Q53HL2	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	32296183
Intra	CDCA8	Q53HL2	INCENP	Homo sapiens	Q9NQS7	Anti Bait CoIP	20739936
Intra	CDCA8	Q53HL2	INCENP	Homo sapiens	Q9NQS7	Y2H	17956729
Intra	CDCA8	Q53HL2	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	17956729
Intra	CDCA8	Q53HL2	NKAPD1	Homo sapiens	Q6ZUT1	Validated Y2H	32296183
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392	Solution Sedimentation	17956729
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392	Pull Down	17099693
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392	Anti Tag CoIP	20739936
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392	Pull Down	18243099
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392	Y2H	17956729
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392	Anti Tag CoIP	17956729
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392	Anti Bait CoIP	20739936
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392	Anti Tag CoIP	33961781
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392	Anti Tag CoIP	17099693
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392-1	Pull Down	16291752
Intra	CDCA8	Q53HL2	BIRC5	Homo sapiens	O15392-2	Pull Down	16291752
Intra	CDCA8	Q53HL2	AURKB	Homo sapiens	Q96GD4	Anti Tag CoIP	20739936
Intra	CDCA8	Q53HL2	AURKB	Homo sapiens	Q96GD4	Anti Tag CoIP	17956729
Intra	CDCA8	Q53HL2	AURKB	Homo sapiens	Q96GD4	Pull Down	18243099
Intra	CDCA8	Q53HL2	AURKB	Homo sapiens	Q96GD4	Anti Bait CoIP	20739936
Intra	CDCA8	Q53HL2	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	CDCA8	Q53HL2	RPRD1B	Homo sapiens	Q9NQG5	Validated Y2H	32296183
Intra	CDCA8	Q53HL2	GAS2L3	Homo sapiens	Q86XJ1	Pull Down	24571573
Intra	CDCA8	Q53HL2	SGO1	Homo sapiens	Q5FBB7	Y2H	20739936
Intra	CDCA8	Q53HL2	SGO1	Homo sapiens	Q5FBB7	Anti Bait CoIP	20739936
Intra	CDCA8	Q53HL2	SGO2	Homo sapiens	Q562F6	Y2H	20739936
Intra	CDCA8	Q53HL2	SGO2	Homo sapiens	Q562F6	Anti Bait CoIP	20739936

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02317	CDCA8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22425	Cdca8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28948	Cdca8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDCA8	RGD	RGD:1566306
Mus musculus	CDCA8	MGD	MGI:1196274
Bos taurus	CDCA8	VGNC	VGNC:27088
Macaca mulatta	CDCA8	VGNC	VGNC:70714
Felis catus	CDCA8	VGNC	VGNC:60670
Canis familiaris	CDCA8	VGNC	VGNC:39017
Others	CDCA8	NCBI