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RPRD1B - regulation of nuclear pre-mRNA domain containing 1B Gene

Also Known as K-H; CREPT; NET60; C20orf77; Kub5-Hera; dJ1057B20.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 58490

About RPRD1B

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,033,746-38,092,364 (from NCBI)

This gene has 9 transcripts (splice variants), 136 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 7.4), lymph node (RPKM 7.2) and 25 other tissues.

Summary

Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in positive regulation of cell population proliferation; regulation of cell cycle process; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]

RPRD1B Products (1)

mRNA	Protein	Name
NM_021215.4	NP_067038.1	regulation of nuclear pre-mRNA domain-containing protein 1B

RPRD1B Protein Structure

CTD_bind

0
100
200
300
326 a.a.

Protein Preferred Names	Protein Names
regulation of nuclear pre-mRNA domain-containing protein 1B	Ku70-binding protein 5-Hera

RPRD1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPRD1B	Q9NQG5	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	STEEP1	Homo sapiens	Q9H5V9	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	STEEP1	Homo sapiens	Q9H5V9	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	RPRD1A	Homo sapiens	Q96P16	Anti Tag CoIP	33961781
Intra	RPRD1B	Q9NQG5	RPRD1A	Homo sapiens	Q96P16	TAP	24981860
Intra	RPRD1B	Q9NQG5	RPRD1A	Homo sapiens	Q96P16	Anti Tag CoIP	28514442
Intra	RPRD1B	Q9NQG5	RPRD1A	Homo sapiens	Q96P16	Anti Tag CoIP	24997600
Intra	RPRD1B	Q9NQG5	PIP4K2B	Homo sapiens	P78356-2	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	PIP4K2B	Homo sapiens	P78356-2	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	VAX1	Homo sapiens	Q5SQQ9-2	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	VAX1	Homo sapiens	Q5SQQ9-2	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	RPRD1A	Homo sapiens	Q96P16-3	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	RPRD1A	Homo sapiens	Q96P16-3	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	VPS37C	Homo sapiens	A5D8V6	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	BIN3	Homo sapiens	Q9NQY0	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	BIN3	Homo sapiens	Q9NQY0	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	BIN3	Homo sapiens	Q9NQY0	Validated Y2H	32296183
Intra	RPRD1B	Q9NQG5	RASSF3	Homo sapiens	Q86WH2	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	RASSF3	Homo sapiens	Q86WH2	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	POLR2A	Homo sapiens	P24928	TAP	24981860
Intra	RPRD1B	Q9NQG5	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	33961781
Intra	RPRD1B	Q9NQG5	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	22264791
Intra	RPRD1B	Q9NQG5	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	28514442
Intra	RPRD1B	Q9NQG5	POLR2A	Homo sapiens	P24928	Pull Down	22264791
Intra	RPRD1B	Q9NQG5	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	24997600
Intra	RPRD1B	Q9NQG5	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	22264791
Intra	RPRD1B	Q9NQG5	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	24997600
Intra	RPRD1B	Q9NQG5	PFDN6	Homo sapiens	O15212	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	PFDN6	Homo sapiens	O15212	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	HOXC4	Homo sapiens	P09017	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	HOXC4	Homo sapiens	P09017	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	RPAP2	Homo sapiens	Q8IXW5	Anti Tag CoIP	24997600
Intra	RPRD1B	Q9NQG5	RPAP2	Homo sapiens	Q8IXW5	Anti Tag CoIP	33961781
Intra	RPRD1B	Q9NQG5	RPAP2	Homo sapiens	Q8IXW5	TAP	24981860
Intra	RPRD1B	Q9NQG5	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	RPRD1B	Q9NQG5	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	RPRD1B	Homo sapiens	Q9NQG5	DLS	24997600
Intra	RPRD1B	Q9NQG5	RPRD1B	Homo sapiens	Q9NQG5	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	RPRD1B	Homo sapiens	Q9NQG5	Crosslink	24997600
Intra	RPRD1B	Q9NQG5	RPRD1B	Homo sapiens	Q9NQG5	X-Ray Diffraction	24997600
Intra	RPRD1B	Q9NQG5	RPRD1B	Homo sapiens	Q9NQG5	GMS	24997600
Intra	RPRD1B	Q9NQG5	RPRD1B	Homo sapiens	Q9NQG5	Solution Sedimentation	24997600
Intra	RPRD1B	Q9NQG5	RPRD1B	Homo sapiens	Q9NQG5	Y2H Array	32296183
Intra	RPRD1B	Q9NQG5	CDCA8	Homo sapiens	Q53HL2	Y2H Prey Pooling	32296183
Intra	RPRD1B	Q9NQG5	CDCA8	Homo sapiens	Q53HL2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Polyneuropathy Due To Drug
Retroperitoneal Leiomyosarcoma
Inflammatory And Toxic Neuropathy
Retroperitoneal Sarcoma
Atrial Tachyarrhythmia With Short Pr Interval	Lown-Ganong-Levine Syndrome Syndrome Of Short P-R Interval, Normal Qrs Complexes, And Supraventricular Tachycardias Lgl Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12217	RPRD1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18875	Rprd1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25366	Rprd1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPRD1B	VGNC	VGNC:34127
Canis familiaris	RPRD1B	VGNC	VGNC:45727
Felis catus	RPRD1B	VGNC	VGNC:64749
Macaca mulatta	RPRD1B	VGNC	VGNC:77024
Mus musculus	RPRD1B	MGD	MGI:1917720
Rattus norvegicus	RPRD1B	RGD	RGD:1304782
Others	RPRD1B	NCBI