RPAP2 - RNA polymerase II associated protein 2 Gene

Also Known as Rtr1; C1orf82

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79871

About RPAP2

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:92,299,059-92,402,056 (from NCBI)

This gene has 3 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 2.5), endometrium (RPKM 2.0) and 25 other tissues.

Summary

Enables RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and snRNA transcription. Located in cytosol and nucleolus. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]

RPAP2 Products (1)

mRNA Protein Name
NM_024813.3 NP_079089.2 putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IMP
IMP: Inferred from mutant phenotype
22137580 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24656813 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
30118681 GOA
Biological Process GO Annotation Evidence References Source
involved in PERK-mediated unfolded protein response IDA
IDA: Inferred from direct assay
30118681 GOA
involved in snRNA transcription IMP
IMP: Inferred from mutant phenotype
22137580 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22137580 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22137580 GOA
part of transcription preinitiation complex IDA
IDA: Inferred from direct assay
22231121 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPAP2 Protein Structure

RPAP2_Rtr1

RPAP2_Rtr1: Rtr1/RPAP2 family (80 - 152)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 612 a.a.
Protein Preferred Names Protein Names

putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

RPAP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPAP2 Q8IXW5 RPRD1A Homo sapiens Q96P16-1
Pull Down
24997600
Intra
RPAP2 Q8IXW5 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
Intra
RPAP2 Q8IXW5 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
Intra
RPAP2 Q8IXW5 PIH1D1 Homo sapiens Q9NWS0
Anti Tag CoIP
35271311
Intra
RPAP2 Q8IXW5 PIH1D1 Homo sapiens Q9NWS0
Validated Y2H
32296183
Intra
RPAP2 Q8IXW5 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
RPAP2 Q8IXW5 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
RPAP2 Q8IXW5 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
Anti Tag CoIP
35271311
Intra
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
Y2H Prey Pooling
32296183
Intra
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
TAP
24981860
Intra
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
Y2H Array
32296183
Intra
RPAP2 Q8IXW5 GPN1 Homo sapiens Q9HCN4
Validated Y2H
32296183
Intra
RPAP2 Q8IXW5 RPRD1B Homo sapiens Q9NQG5
Pull Down
24997600
Intra
RPAP2 Q8IXW5 RPRD1B Homo sapiens Q9NQG5
ITC
24997600
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cholestasis, Intrahepatic, Of Pregnancy, 1

  • ICP1

  • Intrahepatic Cholestasis Of Pregnancy 1

  • Cholestasis, Pregnancy-Related, 1

  • Pregnancy Related Cholestasis 1

  • Cholestasis Of Pregnancy, Intrahepatic 1

  • Obstetric Cholestasis

  • Pregnancy-Related Cholestasis

  • Recurrent Intrahepatic Cholestasis Of Pregnancy

  • Cholestasis, Intrahepatic, Of Pregnancy, Type 1

  • Cholestasis Of Pregnancy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12148 RPAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RPAP2 VGNC VGNC:64729
Rattus norvegicus RPAP2 RGD RGD:1309034
Mus musculus RPAP2 MGD MGI:2141142
Bos taurus RPAP2 VGNC VGNC:34099
Macaca mulatta RPAP2 VGNC VGNC:76828
Others RPAP2 NCBI