PFDN6 - prefoldin subunit 6 Gene

Also Known as HKE2; KE-2; PFD6; H2-KE2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10471

About PFDN6

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,289,197-33,290,934 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele and 198 orthologues. Ubiquitous expression in testis (RPKM 26.0), kidney (RPKM 25.3) and 25 other tissues.

Summary

PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]

PFDN6 Products (4)

mRNA Protein Name
NM_001185181.3 NP_001172110.1 prefoldin subunit 6
NM_001265595.2 NP_001252524.1 prefoldin subunit 6
NM_001265596.1 NP_001252525.1 prefoldin subunit 6
NM_014260.4 NP_055075.1 prefoldin subunit 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
23614719 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein-folding chaperone binding IDA
IDA: Inferred from direct assay
9630229 GOA
enables unfolded protein binding IDA
IDA: Inferred from direct assay
30955883 GOA
Biological Process GO Annotation Evidence References Source
involved in chaperone-mediated protein complex assembly IDA
IDA: Inferred from direct assay
9630229 GOA
involved in negative regulation of amyloid fibril formation IDA
IDA: Inferred from direct assay
23614719 GOA
involved in protein folding IDA
IDA: Inferred from direct assay
30955883 GOA
Cellular Component GO Annotation Evidence References Source
part of RPAP3/R2TP/prefoldin-like complex IPI
IPI: Inferred from physical interaction
31738558 GOA
part of prefoldin complex IDA
IDA: Inferred from direct assay
9630229 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PFDN6 Protein Structure

Prefoldin_2

Prefoldin_2: Prefoldin subunit (10 - 114)

  • 0
  • 100
  • 129 a.a.
Protein Preferred Names Protein Names

prefoldin subunit 6

  • HLA class II region expressed gene KE2

PFDN6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PFDN6 O15212 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra
PFDN6 O15212 MBD3 Homo sapiens O95983-2
Validated Y2H
32296183
Intra
PFDN6 O15212 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
PFDN6 O15212 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra
PFDN6 O15212 FBXO2 Homo sapiens Q9UK22
Validated Y2H
32296183
Intra
PFDN6 O15212 CEBPG Homo sapiens P53567
Validated Y2H
32296183
Intra
PFDN6 O15212 AIMP2 Homo sapiens Q13155
Validated Y2H
32296183
Intra
PFDN6 O15212 RPRD1B Homo sapiens Q9NQG5
Validated Y2H
32296183
Intra
PFDN6 O15212 MAGEB4 Homo sapiens O15481
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Corneal Dystrophy
Corneal Deposit

  • Deposits - Cornea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10360 PFDN6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PFDN6 RGD RGD:1303006
Bos taurus PFDN6 VGNC VGNC:32768
Macaca mulatta PFDN6 VGNC VGNC:75906
Canis familiaris PFDN6 VGNC VGNC:44441
Mus musculus PFDN6 MGD MGI:95908
Others PFDN6 NCBI