FBXO2 - F-box protein 2 Gene

Also Known as FBG1; FBX2; Fbs1; OCP1; NFB42

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26232

About FBXO2

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,648,387-11,654,429 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues and 5 paralogues. Biased expression in brain (RPKM 27.1), adrenal (RPKM 10.3) and 11 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]

FBXO2 Products (1)

mRNA Protein Name
NM_012168.6 NP_036300.2 F-box only protein 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21378169 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO2 Protein Structure

F-box-like

F-box-like: F-box-like (48 - 88)

FBA

FBA: F-box associated region (110 - 295)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

F-box only protein 2

  • F-box gene 1

FBXO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXO2 Q9UK22 PAX4 Homo sapiens Q3KNR5
Y2H Prey Pooling
32296183
Intra
FBXO2 Q9UK22 PAX4 Homo sapiens Q3KNR5
Y2H Array
32296183
Intra
FBXO2 Q9UK22 VSTM1 Homo sapiens Q6UX27-3
Y2H Prey Pooling
32296183
Intra
FBXO2 Q9UK22 VSTM1 Homo sapiens Q6UX27-3
Y2H Array
32296183
Intra
FBXO2 Q9UK22 SIAE Homo sapiens Q9HAT2
Anti Tag CoIP
33961781
Intra
FBXO2 Q9UK22 SKP1 Homo sapiens P63208
MAPPIT
32296183
Intra
FBXO2 Q9UK22 SKP1 Homo sapiens P63208
Validated Y2H
25416956
Intra
FBXO2 Q9UK22 PFDN6 Homo sapiens O15212
Y2H Array
32296183
Intra
FBXO2 Q9UK22 PFDN6 Homo sapiens O15212
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

FBXO2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89729 FBXO2 Antibody (YA9073) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04797 FBXO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FBXO2 VGNC VGNC:49675
Rattus norvegicus FBXO2 RGD RGD:621751
Bos taurus FBXO2 VGNC VGNC:28897
Mus musculus FBXO2 MGD MGI:2446216
Macaca mulatta FBXO2 VGNC VGNC:72486
Felis catus FBXO2 VGNC VGNC:107540
Others FBXO2 NCBI