FBXO2 Antibody (YA9073)
(Synonyms: FBX2, FBXO2, F-box only protein 2)
Based on 1 Customer Validation
FBXO2 Antibody (YA9073) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FBXO2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, IF-Tissue, IP, ELISA
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Reactivity :
human
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:50-500 | 1:50-500 | 1-2μg per 100-500μg Total protein | 1:50-3000 |
Product Details
FBXO2 Antibody (YA9073) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FBXO2.
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Host Mouse
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Species Reactivityhuman
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Calculated Molecular Weight Predicted band size: 42 kDa
OMIM: 607112
A synthesized peptide derived from human FBXO2.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
FBXO2 is a Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity)
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Subcellular Localization
Cytoplasm; Microsome membrane
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Isoforms & Post-Translational Modification
FBXO2 has an amino acid length of 296, molecular weight is 33328 Da
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Subunit
Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2.
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SwissProt ID
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Synonyms
FBX2, FBXO2, F-box only protein 2
Documentation
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