BIN3 - bridging integrator 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55909

About BIN3

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,620,418-22,669,121 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 13.5), adrenal (RPKM 7.2) and 25 other tissues.

Summary

The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of Other processes. [provided by RefSeq, Jul 2008]

BIN3 Products (2)

mRNA Protein Name
NM_001363046.2 NP_001349975.1 bridging integrator 3 isoform 2
NM_018688.6 NP_061158.1 bridging integrator 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18654987 GOA
Biological Process GO Annotation Evidence References Source
involved in protein localization IMP
IMP: Inferred from mutant phenotype
11274158 GOA
involved in unidimensional cell growth IMP
IMP: Inferred from mutant phenotype
11274158 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIN3 Protein Structure

BAR

BAR: BAR domain (16 - 224)

  • 0
  • 100
  • 200
  • 253 a.a.
Protein Preferred Names Protein Names

bridging integrator 3

BIN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BIN3 Q9NQY0 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
BIN3 Q9NQY0 DNMBP Homo sapiens Q6XZF7
Anti Tag CoIP
35271311
Intra
BIN3 Q9NQY0 DNMBP Homo sapiens Q6XZF7
Anti Tag CoIP
33961781
Intra
BIN3 Q9NQY0 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
BIN3 Q9NQY0 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 10

  • RP10

  • Retinitis Pigmentosa-10

  • Retinitis Pigmentosa, Type 10
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15133 PTP1B-IN-3 Inhibitor 99.69% Unkown
HY-147830 PDE4B-IN-3 Inhibitor 99.37% Unkown
HY-15133A PTP1B-IN-3 diammonium Inhibitor 95.38% Unkown
HY-139600 KDM2B-IN-3 Inhibitor / Unkown
HY-146429 NaPi2b-IN-3 Inhibitor / Unkown
HY-146670 KDM5B-IN-3 Inhibitor / Unkown
HY-147605 Factor B-IN-3 Inhibitor / Unkown
HY-149379 DNA gyrase B-IN-3 Inhibitor / Unkown
HY-151885 Dual AChE-MAO B-IN-3 Inhibitor / Unkown
HY-D2988 BIN-3 / Unkown
HY-RS01506 BIN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BIN3 MGD MGI:1929883
Macaca mulatta BIN3 VGNC VGNC:70252
Canis familiaris BIN3 VGNC VGNC:54923
Felis catus BIN3 VGNC VGNC:60118
Rattus norvegicus BIN3 RGD RGD:1308253
Bos taurus BIN3 VGNC VGNC:52607
Others BIN3 NCBI