2. Neuronal Signaling
  3. Cholinesterase (ChE) Monoamine Oxidase
  4. Dual AChE-MAO B-IN-3

Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitior, with IC50 values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. Dual AChE-MAO B-IN-3 can be used for Alzheimer’s disease (AD) research.

For research use only. We do not sell to patients.

Dual AChE-MAO B-IN-3 Chemical Structure

Dual AChE-MAO B-IN-3 Chemical Structure

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Dual AChE-MAO B-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All Cholinesterase (ChE) Isoform Specific Products:

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AChE BChE

View All Monoamine Oxidase Isoform Specific Products:

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MAO-A MAO-B

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitior, with IC50 values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. Dual AChE-MAO B-IN-3 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target

MAO-B

0.41 ± 0.0 μM (IC50)

EeAChE

0.58 ± 0.0 μM (IC50)

In Vitro

Dual AChE-MAO B-IN-3 (compound C10) (0-100 μM, 24 h) exhibits low neurotoxicity, and (0-10 μM, 24 h) potently inhibits AChE enzymatic activity[1].
Dual AChE-MAO B-IN-3 more effectively protects against mitochondrial dysfunction and oxidation than Donepezil (HY-14566), strongly inhibits AChE-induced amyloid aggregation, and moderately reduces glutaraldehyde-induced phosphorylation of tau protein in SH-SY5Y cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dual AChE-MAO B-IN-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 10 μM, 50 μM, 100 μM
Incubation Time: 24 h
Result: Exhibited a nonsignificant reduction in cell viabilities up to the maximum tested concentration of 100 μM. The percentage cell viability at 10-100 μM was observed in the range of 96.92−99.58%. Showed that compound C10 was not toxic to SH-SY5Y neuroblastoma cells at concentrations up to 100 μM.
In Vivo

Dual AChE-MAO B-IN-3 (compound C10) (10 mg/kg, IP, once daily for 10 consecutive days) displays largely enhanced improvements in cognitive behaviors and spatial memory in a scopolamine-induced AD mice model with better efficacy than Donepezil (HY-14566)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (female, 8-10 weeks, 25-30 g)[1]
Dosage: 10 mg/kg
Administration: IP, once daily for 10 consecutive days
Result: Significantly ameliorated the cognitive impairment in a scopolamine-induced mice model.
Molecular Weight

505.53

Formula

C30H26F3NO3
SMILES

O=C(/C(CO1)=C/C2=CCN(CC2)CC3=CC=CC=C3)C(C=C4)=C1C=C4OCC(C=C5)=CC=C5C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dual AChE-MAO B-IN-3 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dual AChE-MAO B-IN-3Cholinesterase (ChE)Monoamine OxidaseMAOSH-SY5Y cellsAlzheimer’s diseaselow neurotoxicityElectrophorus electricus AChEInhibitorinhibitorinhibit

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