Dual AChE-MAO B-IN-3
Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitior, with IC50 values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. Dual AChE-MAO B-IN-3 can be used for Alzheimer’s disease (AD) research.
For research use only. We do not sell to patients.
- Formula: C30H26F3NO3
- Molecular Weight:505.53
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
MAO-B 0.41 ± 0.0 μM (IC50) |
EeAChE 0.58 ± 0.0 μM (IC50) |
Dual AChE-MAO B-IN-3 (compound C10) (0-100 μM, 24 h) exhibits low neurotoxicity, and (0-10 μM, 24 h) potently inhibits AChE enzymatic activity[1].
Dual AChE-MAO B-IN-3 more effectively protects against mitochondrial dysfunction and oxidation than Donepezil (HY-14566), strongly inhibits AChE-induced amyloid aggregation, and moderately reduces glutaraldehyde-induced phosphorylation of tau protein in SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:SH-SY5Y cells
-
Concentration:10 μM, 50 μM, 100 μM
-
Incubation Time:24 h
-
Result:Exhibited a nonsignificant reduction in cell viabilities up to the maximum tested concentration of 100 μM. The percentage cell viability at 10-100 μM was observed in the range of 96.92−99.58%. Showed that compound C10 was not toxic to SH-SY5Y neuroblastoma cells at concentrations up to 100 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ICR mice (female, 8-10 weeks, 25-30 g)[1]
-
Dosage:10 mg/kg
-
Administration:IP, once daily for 10 consecutive days
-
Result:Significantly ameliorated the cognitive impairment in a scopolamine-induced mice model.
Chemical Information
-
Molecular Weight 505.53
-
Formula C30H26F3NO3
-
SMILES
O=C(/C(CO1)=C/C2=CCN(CC2)CC3=CC=CC=C3)C(C=C4)=C1C=C4OCC(C=C5)=CC=C5C(F)(F)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dual AChE-MAO B-IN-3 Related Classifications
HY-151885 Related Classifications
Powered by Bioz