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Myosin Heavy Chain Antibody (YA5348)

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Myosin Heavy Chain Antibody (YA5348) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Myosin Heavy Chain.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Application:

    ICC/IF

  • Reactivity :

    Human, Mouse, Rat, FruitFly, Nematode

  • Formulation:

    Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:100

Product Details

Description

Myosin Heavy Chain Antibody (YA5348) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Myosin Heavy Chain.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat, FruitFly, Nematode
  • Observed Molecular Weight
    Observed band size: 220 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Immunogen

Synthetic Peptide of Myosin Heavy Chain

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

RRID

AB_3719030

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Myosin Heavy Chain is a P05976: Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function
    P08590: Regulatory light chain of myosin. Does not bind calcium
    P10916: Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force.
    P11055: Muscle contraction
    P12829: Regulatory light chain of myosin. Does not bind calcium
    P12882: Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility
    P13533: Muscle contraction
    P60660: Regulatory light chain of myosin. Does not bind calcium
    [1][2].

  • Subcellular Localization

    P10916: Cytoplasm, myofibril, sarcomere, A band
    P11055: Cytoplasm, myofibril
    P12882: Cytoplasm, myofibril
    P13533: Cytoplasm, myofibril

  • Expression


    Tissue_specificity: P10916: Highly expressed in type I muscle fibers
    P11055: Expressed in fetal bone, thymus, placenta, heart, brain, and liver
    Q02045: Expressed in fetal skeletal muscle and retina

  • Subunit

    P05976: Myosin is a hexamer of 2 heavy chains and 4 light chains. Does not bind calcium
    P08590: Myosin is a hexamer of 2 heavy chains and 4 light chains
    P10916: Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with MYOC (PubMed:11773029)
    P11055: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC) , 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2)
    P12829: Myosin is a hexamer of 2 heavy chains and 4 light chains
    P12882: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC) , 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with SLC26A5 (PubMed:39482536)
    P13533: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC) , 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2)
    P60660: Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6
    Q02045: Myosin is a hexamer of 2 heavy chains and 4 light chains

  • SwissProt ID

    P05976 / P08590 / P10916 / P11055 / P12829 / P12882 / P13533 / P60660 / Q02045

  • Gene ID
    4632 [NCBI] / 4634 [NCBI] / 4633 [NCBI] / 4621 [NCBI] / 4635 [NCBI] / 4619 [NCBI] / 4624 [NCBI] / 4637 [NCBI] / 4636 [NCBI]

Myosin Heavy Chain Antibody (YA5348) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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