MYL1 - myosin light chain 1 Gene

Also Known as MLC1; MLC-1; MLC1F; MLC3F; MLC1/3; MYOFTA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4632

About MYL1

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:210,290,150-210,315,174 (from NCBI)

This gene has 4 transcripts (splice variants), 293 orthologues, 4 paralogues and is associated with 3 phenotypes. Restricted expression toward prostate (RPKM 145.3).

Summary

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a Myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

MYL1 Products (2)

mRNA Protein Name
NM_079420.3 NP_524144.1 myosin light chain 1/3, skeletal muscle isoform isoform 1f
NM_079422.3 NP_524146.1 myosin light chain 1/3, skeletal muscle isoform isoform 3f

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables structural constituent of muscle IMP
IMP: Inferred from mutant phenotype
30215711 GOA
Biological Process GO Annotation Evidence References Source
involved in muscle contraction IDA
IDA: Inferred from direct assay
8145163 GOA
Cellular Component GO Annotation Evidence References Source
located in myofibril IDA
IDA: Inferred from direct assay
8145163 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYL1 Protein Structure

EF-hand_6

EF-hand_6: EF-hand domain (54 - 83)

  • 0
  • 100
  • 194 a.a.
Protein Preferred Names Protein Names

myosin light chain 1/3, skeletal muscle isoform

  • A1 catalytic

MYL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85656 Myosin Heavy Chain Antibody (YA5348) ICC/IF Human, Mouse, Rat, FruitFly, Nematode

Related Diseases

Diseases Alias
Myopathy, Congenital, With Fast-Twitch Fiber Atrophy

  • Congenital Myopathy With Reduced Type 2 Muscle Fibers

  • MYOFTA

  • Congenital Myopathy With Fast-Twitch Fiber Atrophy

  • Congenital Myopathy With Reduced Type Ii Muscle Fibers

  • Congenital Myopathy With Type 2 Muscle Fiber Atrophy

  • Congenital Myopathy With Type Ii Fiber Atrophy

  • Myopathy, Congenital, With Fast-Twitch Type Ii Fiber Atrophy
Crab Allergy

  • Green Mud Crab Allergy

  • Scylla Paramamosain Allergy
Respiratory Failure

  • Acute Respiratory Failure

  • Chronic Respiratory Failure

  • Respiratory Insufficiency

  • Acute-On-Chronic Respiratory Failure

  • Respiratory Disease

  • Acute And Chronic Respiratory Failure

  • Respiratory Insufficiency/Failure

  • Chronic Respiratory Disease

  • Pulmonary Valve Insufficiency

  • Chronic Disease Of Respiratory System

  • Respiration Disorders

  • Respiratory Tract Diseases

  • Lung Failure Nos

  • Pulmonary Failure

  • Arf - [Acute Respiratory Failure]

  • Acute Respiratory Insufficiency

  • Acute Pulmonary Insufficiency

  • Acute Respiration Failure

  • Chronic Respiration Failure
Myopathy

  • Muscular Diseases

  • Myopathies
Crustacean Allergy
Myocardial Stunning
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08909 MYL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MYL1 VGNC VGNC:80287
Rattus norvegicus MYL1 RGD RGD:1598796
Canis familiaris MYL1 VGNC VGNC:43541
Mus musculus MYL1 MGD MGI:97269
Macaca mulatta MYL1 VGNC VGNC:99384
Bos taurus MYL1 VGNC VGNC:31799
Others MYL1 NCBI