MYL4 - myosin light chain 4 Gene

Also Known as GT1; ALC1; AMLC; PRO1957

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4635

About MYL4

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,189,433-47,227,650 (from NCBI)

This gene has 10 transcripts (splice variants), 290 orthologues, 4 paralogues and is associated with 2 phenotypes. Restricted expression toward heart (RPKM 587.0).

Summary

Myosin is a hexameric ATPase cellular motor protein. It is composed of two Myosin heavy chains, two nonphosphorylatable Myosin alkali light chains, and two phosphorylatable Myosin regulatory light chains. This gene encodes a Myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

MYL4 Products (2)

mRNA Protein Name
NM_001002841.2 NP_001002841.1 myosin light chain 4
NM_002476.2 NP_002467.1 myosin light chain 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IMP
IMP: Inferred from mutant phenotype
9738905 GOA
enables actin monomer binding IDA
IDA: Inferred from direct assay
9180271 GOA
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
14985854 GOA
involved in positive regulation of ATP-dependent activity IMP
IMP: Inferred from mutant phenotype
9738905 GOA
involved in regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
16675844 GOA
Cellular Component GO Annotation Evidence References Source
located in A band IMP
IMP: Inferred from mutant phenotype
14985854 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYL4 Protein Structure

EF-hand_6

EF-hand_6: EF-hand domain (55 - 86)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

myosin light chain 4

  • atrial myosin light chain 1

MYL4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85656 Myosin Heavy Chain Antibody (YA5348) ICC/IF Human, Mouse, Rat, FruitFly, Nematode

Related Diseases

Diseases Alias
Atrial Fibrillation, Familial, 18

  • ATFB18

  • Fibrillation, Atrial, Familial, Type 18
Familial Atrial Fibrillation

  • Atrial Fibrillation, Familial

  • Atfb

  • Atrial Fibrillation Autosomal Dominant

  • Autosomal Dominant Atrial Fibrillation

  • Auricular Fibrillation

  • Atrial Fibrillation

  • Atrial Fibrillation, Familial, 1
Atrial Fibrillation

  • A-Fib

  • Fibrillation, Atrial

  • Af - [Atrial Fibrillation]

  • Rapid Atrial Fibrillation

  • A Fib - [Atrial Fibrillation]
Aortic Valve Disease 2

  • Aortic Valve Stenosis

  • Aortic Stenosis

  • Rheumatic Aortic Stenosis

  • AOVD2

  • Bicuspid Aortic Valve

  • Rheumatic Aortic Valve Stenosis

  • Valvular Aortic Stenosis

  • Aortic Valve Disease, Type 2

  • Aortic Valve Stricture

  • Aortic Valve Obstruction

  • Obstructed Aorta Valve

  • Rheumatic Aortic Obstruction

  • Rheumatic Aortic Valve Obstruction

  • Rheumatic Aortic Stricture

  • Aortic Valve Regurgitation

  • Aortic Insufficiency With Stenosis

  • Rheumatic Aortic Valve Stenosis With Insufficiency

  • Rheumatic Aortic Stenosis With Incompetence

  • Rheumatic Aortic Stenosis With Regurgitation
Acute Myocardial Infarction

  • Cardiac Attack

  • Heart Attack
Pleomorphic Rhabdomyosarcoma

  • Adult Pleomorphic Rhabdomyosarcoma

  • Anaplastic Rhabdomyosarcoma

  • Pleomorphic Rhabdomyosarcoma, Adult Type
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Congenital Fiber-Type Disproportion

  • Congenital Fiber Type Disproportion

  • Cftdm

  • Congenital Myopathy With Fiber Type Disproportion

  • Cftd

  • Congenital Fiber-Type Disproportion Myopathy

  • Fiber-Type Disproportion Myopathy, Congenital

  • Myopathy, Congenital With Fiber-Type Disproportion
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08916 MYL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21385 Myl4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27904 Myl4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MYL4 RGD RGD:1591197
Canis familiaris MYL4 VGNC VGNC:55648
Mus musculus MYL4 MGD MGI:97267
Felis catus MYL4 VGNC VGNC:68384
Bos taurus MYL4 VGNC VGNC:31802
Macaca mulatta MYL4 VGNC VGNC:75105
Others MYL4 NCBI