Art. -Nr.: HY-12759

CARM1-IN-1

Name: CARM1-IN-1
Brand: MedChemExpress
SKU: HY-12759
Price: 100.00 USD
Availability: InStock
Rating: 5 (4 reviews)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

CARM1-IN-1 (compound 7g) is a highly potent and selective inhibitor of CARM1 (IC₅₀=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC₅₀ >667 μM). CARM1-IN-1 inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 95.0%
CAS. Nr.: 1020399-49-8
Formel: C₂₆H₂₁Br₂NO₃
Molecular Weight:555.26

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

CARM1-IN-1 Chemical Structure

CAS. Nr.: 1020399-49-8

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

PRMT4

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

In Vitro

CARM1-IN-1 (compound 7g) (100 μM; 90 min) inhibits CARM1-mediated methylation of different substrates (PABP1, CA150, SmB, and H3), such as Flag-PABP1 methylation, without inhibitory activity against HKMTs^[1].
CARM1-IN-1 (compound 7g) (8 μM; 42-44 h) inhibits PSA promoter activity in luciferase assay in LNCaP cells, without affecting cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PCR LNCa cells
Concentration:

1 μM, 2 μM, 4 μM, 6 μM, 8 μM
Incubation Time:

42-48 h
Result:

Showed a significant dose-dependent reduction of the PSA promoter activity, at concentration that did not affect cell viability.

Related Protocols :

Chemical Information

CAS. Nr. 1020399-49-8
Appearance Solid
Molecular Weight 555.26
Formel C₂₆H₂₁Br₂NO₃
Color Yellow to orange
SMILES

O=C1/C(CN(CC2=CC=CC=C2)C/C1=C\C3=CC=C(O)C(Br)=C3)=C/C4=CC=C(O)C(Br)=C4
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (4)

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Journal Impact Factor

Sci Bull (Beijing)

TRIM28 protects CARM1 from proteasome-mediated degradation to prevent colorectal cancer metastasis. [Abstract]

2019 Jul 30;64(14):986-997. PMID: 36659810
Theriogenology

Unveiling the effects of regulating endogenous growth factors and apoptosis via DGCR8 on yak blastocyst formation. [Abstract]

2026 Feb 1:251:117750. PMID: 41240745
Theriogenology

Paraspeckles / CARM1 mediates the regulation of OEVs on cell differentiation during in vitro embryonic development of yak. [Abstract]

2024 Jul 15:223:74-88. PMID: 38692037
Res Sq

2024 Jun 04.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 35 mg/mL (63.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8010 mL

9.0048 mL

18.0096 mL

5 mM

0.3602 mL

1.8010 mL

3.6019 mL

10 mM

0.1801 mL

0.9005 mL

1.8010 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (4.50 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8010 mL	9.0048 mL	18.0096 mL	45.0240 mL
	5 mM	0.3602 mL	1.8010 mL	3.6019 mL	9.0048 mL
	10 mM	0.1801 mL	0.9005 mL	1.8010 mL	4.5024 mL
	15 mM	0.1201 mL	0.6003 mL	1.2006 mL	3.0016 mL
	20 mM	0.0900 mL	0.4502 mL	0.9005 mL	2.2512 mL
	25 mM	0.0720 mL	0.3602 mL	0.7204 mL	1.8010 mL
	30 mM	0.0600 mL	0.3002 mL	0.6003 mL	1.5008 mL
	40 mM	0.0450 mL	0.2251 mL	0.4502 mL	1.1256 mL
	50 mM	0.0360 mL	0.1801 mL	0.3602 mL	0.9005 mL
	60 mM	0.0300 mL	0.1501 mL	0.3002 mL	0.7504 mL

Bioz

Keywords

CARM1-IN-1

4 Cited Publications

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CARM1-IN-1

Publications Citing Use of MedChemExpress (MCE) CARM1-IN-1

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen