1. Epigenetics
  2. Histone Methyltransferase
  3. CARM1-IN-1 hydrochloride

CARM1-IN-1 hydrochloride 

Cat. No.: HY-12759A Purity: ≥98.0%
Handling Instructions

CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM).

For research use only. We do not sell to patients.

CARM1-IN-1 hydrochloride Chemical Structure

CARM1-IN-1 hydrochloride Chemical Structure

CAS No. : 2070018-31-2

Size Price Stock Quantity
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
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200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). IC50 value: 8.6 uM [1] Target: CRAM1 inhibitor in vitro: CARM1-IN-1 displays high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, CARM1-IN-1 shows a significant dose-dependent reduction of the PSA promoter activity.

Molecular Weight

591.72

Formula

C₂₆H₂₂Br₂ClNO₃

CAS No.
SMILES

[H]Cl.O=C1/C(CN(CC2=CC=CC=C2)C/C1=C\C3=CC=C(O)C(Br)=C3)=C/C4=CC=C(O)C(Br)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 38 mg/mL (64.22 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6900 mL 8.4499 mL 16.8999 mL
5 mM 0.3380 mL 1.6900 mL 3.3800 mL
10 mM 0.1690 mL 0.8450 mL 1.6900 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.08 mg/mL (3.52 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Keywords:

CARM1-IN-1Histone MethyltransferaseInhibitorinhibitorinhibit

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Product Name:
CARM1-IN-1 hydrochloride
Cat. No.:
HY-12759A
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