2070018-31-2
Chemical Structure
CARM1-IN-1 hydrochloride
- CAS No.: 2070018-31-2
- Formula:C26H22Br2ClNO3
- Molecular Weight:591.72
IUPAC Name: 1-benzyl-3,5-bis((E)-3-bromo-4-hydroxybenzylidene)piperidin-4-one hydrochloride
InChIKey: QLPNYHLFFVKOAN-CUBOLJEZSA-N
SMILES: [H]Cl.O=C1/C(CN(CC2=CC=CC=C2)C/C1=C\C3=CC=C(O)C(Br)=C3)=C/C4=CC=C(O)C(Br)=C4
Biological Activity: CARM1-IN-1 (compound 7g) hydrochloride is a highly potent and selective inhibitor of CARM1 (IC50=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC50 >667 μM). CARM1-IN-1 hydrochloride inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 hydrochloride also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity[1].
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CARM1-IN-1 hydrochloride | 95.17% | CARM1-IN-1 (compound 7g) hydrochloride is a highly potent and selective inhibitor of CARM1 (IC50=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC50 >667 μM). CARM1-IN-1 hydrochloride inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 hydrochloride also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity. | ||||||||||||||||||||
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Keywords
