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FLDP-8 is a curcuminoid analogues, has potent anti-cancer effects. FLDP-8 can induce cell death with an IC50 value of 4 μM in LN-18 cells.

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FLDP-8 Chemical Structure

FLDP-8 Chemical Structure

CAS No. : 861968-02-7

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FLDP-8 Related Antibodies

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Description

FLDP-8 is a curcuminoid analogues, has potent anti-cancer effects. FLDP-8 can induce cell death with an IC50 value of 4 μM in LN-18 cells[1].

IC50 & Target

IC50: 4 μM (LN-18 cells)[1]
In Vitro

FLDP-8 (0-40 μM, 24 h) induces cell death process with an IC50 value of 4 μM in a concentration-dependent manner in LN-18 cells, which involves oxidative stress[1].
FLDP-8 (1.25 μM, 2.5 μM, 24 h) induces significant S-phase cell cycle arrest[1].
FLDP-8 (2.5 μM, 5 μM, 24 h) exhibits anti-cancer effects with anti-proliferative, anti-migratory and high potency of BBB permeable properties in Glioblastoma multiforme (GBM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FLDP-8 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: LN-18 cells and HBEC‑5i cells
Concentration: 0.625 μM -20 μM (LN‑18 cells) 1.25 μM - 40 μM (HBEC‑5i cells)
Incubation Time: 24 h
Result: Induced cytotoxicity on LN‑18 cells and HBEC‑5i cells.

Cell Cycle Analysis[1]

Cell Line: LN-18 cells
Concentration: 1.25 μM, 2.5 μM
Incubation Time: 24 h
Result: Induced arrest in S phase in a concentration-dependent manner.

Cell Invasion Assay[1]

Cell Line: LN-18 cells
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Inhibited the invasion of LN‑18 cells.

Cell Migration Assay [1]

Cell Line: LN-18 cells
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Showed a high potential in inhibiting the migration of LN-18 cells.
Molecular Weight

381.42

Formula

C22H23NO5
CAS No.
SMILES

O=C1/C(CN(C)C/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FLDP-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLDP-8861968-02-7FLDP8FLDP 8Otherscurcuminoid analoguesGlioblastoma multiforme (GBM)BBBcancerLN-18HBEC5iInhibitorinhibitorinhibit

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