2. Epigenetics
  3. Histone Methyltransferase
  4. AK442

AK442 is a selective PRMT4 (CARM1) inhibitor with an IC50 of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research.

For research use only. We do not sell to patients.

AK442

AK442 Chemical Structure

CAS No. : 3062376-05-7

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AK442 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

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Description

AK442 is a selective PRMT4 (CARM1) inhibitor with an IC50 of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research[1].

IC50 & Target[1]

PRMT4

 

In Vitro

AK442 (10 μM; 6.5 h) binds to PRMT4 in MDA-MB-231 cells and increases the thermal stability of PRMT4 by 2 °C compared with the DMSO control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AK442 Related Antibodies
Molecular Weight

686.20

Formula

C35H40ClN9O4
CAS No.
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CN(CCNCC4=CC(C5=CC=C(C=C5)Cl)=CC=C4)CCNC(NCC6=CC=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AK442 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AK4423062376-05-7AK 442AK-442Histone MethyltransferasePRMT6PRMT8PRMT1CARM1PRMT7PRMT5breast cancerMDA-MB-231 cellsPRMT4PRMT3Inhibitorinhibitorinhibit

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HY-183653
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