1. Cell Cycle/DNA Damage Epigenetics
  2. PARP Histone Methyltransferase
  3. PARP/EZH2-IN-1

PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.

For research use only. We do not sell to patients.

PARP/EZH2-IN-1 Chemical Structure

PARP/EZH2-IN-1 Chemical Structure

CAS No. : 2687273-52-3

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Description

PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.

IC50 & Target

PARP-1

6.87 nM (IC50)

EZH2

36.51 nM (IC50)

Molecular Weight

768.83

Formula

C43H41FN8O5

CAS No.
SMILES

O=C(C1=C(C(NC(C)=O)=CC(C2=CC=C(N=C2)N3CCN(CC3)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O)=C1)C)NCC7=C(C=C(NC7=O)C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PARP/EZH2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PARP/EZH2-IN-1
Cat. No.:
HY-132885
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