2687273-52-3
Chemical Structure
PARP/EZH2-IN-1
- CAS No.: 2687273-52-3
- Formula:C43H41FN8O5
- Molecular Weight:768.83
IUPAC Name: 3-acetamido-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(6-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)pyridin-3-yl)-2-methylbenzamide
InChIKey: VKTSBOIQJNMQAL-UHFFFAOYSA-N
SMILES: O=C(C1=C(C(NC(C)=O)=CC(C2=CC=C(N=C2)N3CCN(CC3)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O)=C1)C)NCC7=C(C=C(NC7=O)C)C
Biological Activity: PARP/EZH2-IN-1 is a first-in-class dual PARP-1/EZH2 inhibitor with IC50 values of 6.87 nM and 36.51 nM, respectively. PARP/EZH2-IN-1 induces autophagy in cancer cells and shows potent antiproliferative activity in BRCA wild-type triple-negative breast cancer cells[1].
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PARP/EZH2-IN-1 | PARP/EZH2-IN-1 is a first-in-class dual PARP-1/EZH2 inhibitor with IC50 values of 6.87 nM and 36.51 nM, respectively. PARP/EZH2-IN-1 induces autophagy in cancer cells and shows potent antiproliferative activity in BRCA wild-type triple-negative breast cancer cells. | |||||||||||||||||||||
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Keywords
