TRIM7 - tripartite motif containing 7 Gene

Also Known as GNIP; RNF90

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81786

About TRIM7

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,193,924-181,205,196 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 80 paralogues. Biased expression in skin (RPKM 5.6), esophagus (RPKM 2.8) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

TRIM7 Products (6)

mRNA Protein Name
NM_033342.4 NP_203128.1 E3 ubiquitin-protein ligase TRIM7 isoform 4
NM_203293.3 NP_976038.1 E3 ubiquitin-protein ligase TRIM7 isoform 1
NM_203294.2 NP_976039.1 E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203295.2 NP_976040.1 E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203296.2 NP_976041.1 E3 ubiquitin-protein ligase TRIM7 isoform 3
NM_203297.2 NP_976042.1 E3 ubiquitin-protein ligase TRIM7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
35893676 GOA
Biological Process GO Annotation Evidence References Source
involved in antiviral innate immune response IDA
IDA: Inferred from direct assay
35893676 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
35893676 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11331580 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11331580 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM7 Protein Structure

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (29 - 81)

zf-B_box

zf-B_box: B-box zinc finger (128 - 166)

PRY

PRY: SPRY-associated domain (344 - 392)

SPRY

SPRY: SPRY domain (394 - 502)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 511 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM7

  • RING finger protein 90

TRIM7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRIM7 Q9C029 CFL2 Homo sapiens Q9Y281
Validated Y2H
32296183
Intra
TRIM7 Q9C029 IRAK4 Homo sapiens Q9NWZ3
Validated Y2H
32296183
Intra
TRIM7 Q9C029 CTNNAL1 Homo sapiens Q9UBT7
Validated Y2H
32296183
Intra
TRIM7 Q9C029 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
Intra
TRIM7 Q9C029 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra
TRIM7 Q9C029 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
Intra
TRIM7 Q9C029 MAD2L2 Homo sapiens Q9UI95
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 7

  • NS7

  • Noonan Syndrome, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159082 E3 ligase Ligand 28 / Unkown
HY-RS15069 TRIM7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22880 Trim7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29394 Trim7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRIM7 VGNC VGNC:36351
Felis catus TRIM7 VGNC VGNC:66552
Macaca mulatta TRIM7 VGNC VGNC:79022
Rattus norvegicus TRIM7 RGD RGD:1307328
Mus musculus TRIM7 MGD MGI:2137353
Canis familiaris TRIM7 VGNC VGNC:47836
Others TRIM7 NCBI