PTPN6 - protein tyrosine phosphatase non-receptor type 6 Gene

Also Known as HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5777

About PTPN6

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,946,577-6,961,316 (from NCBI)

This gene has 23 transcripts (splice variants), 198 orthologues, 35 paralogues and is associated with 61 phenotypes. Broad expression in spleen (RPKM 76.2), lymph node (RPKM 74.9) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

PTPN6 Products (3)

mRNA	Protein	Name
NM_002831.6	NP_002822.2	tyrosine-protein phosphatase non-receptor type 6 isoform 1
NM_080548.5	NP_536858.1	tyrosine-protein phosphatase non-receptor type 6 isoform 2
NM_080549.4	NP_536859.1	tyrosine-protein phosphatase non-receptor type 6 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphorylation-dependent protein binding	IPI IPI: Inferred from physical interaction	11162587	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	11986327	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7228577	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11266449	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	17562706	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	10206955	GOA
enables transmembrane receptor protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	11266449	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CD27 signaling pathway	IDA IDA: Inferred from direct assay	38354704	GOA
involved in T cell activation	IDA IDA: Inferred from direct assay	38354704	GOA
involved in cell differentiation	IDA IDA: Inferred from direct assay	11266449	GOA
involved in negative regulation of B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	35941532	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	23896411	GOA
involved in negative regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	34811497	GOA
involved in negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	19749791	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	17562706	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9285411	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19749791	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19838216	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	11266449	GOA
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	11266449	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19838216	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	9065461	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10940933	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19838216	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	23896411	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	17562706	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN6 Protein Structure

SH2

Y_phosphatase

0
100
200
300
400
500
595 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 6	hematopoietic cell phosphatase

PTPN6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPN6	P29350	KDR	Homo sapiens	P35968	Ub Reconstruction	28065597
Intra	PTPN6	P29350	LCK	Homo sapiens	P06239	Protein Kinase Assay	8114715
Intra	PTPN6	P29350	NFAT5	Homo sapiens	O94916-1	Anti Bait CoIP	20351292
Intra	PTPN6	P29350	NFAT5	Homo sapiens	O94916-1	Anti Tag CoIP	20351292
Intra	PTPN6	P29350	PTPN12	Homo sapiens	Q05209	Anti Tag CoIP	31980649
Intra	PTPN6	P29350	PTPN12	Homo sapiens	Q05209	Anti Tag CoIP	33961781
Intra	PTPN6	P29350	LILRB4	Homo sapiens	Q8NHJ6	Anti Bait CoIP	18802077
Intra	PTPN6	P29350	LILRB1	Homo sapiens	Q8NHL6	Anti Bait CoIP	18802077
Intra	PTPN6	P29350	LILRB2	Homo sapiens	Q8N423	Anti Bait CoIP	18802077
Intra	PTPN6	P29350	LILRB3	Homo sapiens	O75022	Anti Bait CoIP	18802077
Intra	PTPN6	P29350	THEMIS	Homo sapiens	Q8N1K5	Anti Bait CoIP	25535246
Intra	PTPN6	P29350	CD33	Homo sapiens	P20138	CoIP	10206955
Intra	PTPN6	P29350	CD33	Homo sapiens	P20138	CoIP	10556798
Intra	PTPN6	P29350	CD33	Homo sapiens	P20138	Enzymatic Study	10556798
Intra	PTPN6	P29350	IGF1R	Homo sapiens	P08069	Ub Reconstruction	28065597
Intra	PTPN6	P29350	CD37	Homo sapiens	P11049	Anti Bait CoIP	22624718
Intra	PTPN6	P29350	EPOR	Homo sapiens	P19235	Affinity Chrom	7228577
Intra	PTPN6	P29350	EPOR	Homo sapiens	P19235	Pull Down	7228577
Intra	PTPN6	P29350	EPOR	Homo sapiens	P19235	Pull Down	7528577
Cross	PTPN6	P29350	tir	Escherichia coli O157:H7	Q7DB77	Anti Tag CoIP	23001144
Intra	PTPN6	P29350	PECAM1	Homo sapiens	P16284	Pull Down	9774457
Intra	PTPN6	P29350	PECAM1	Homo sapiens	P16284	SPR	9774457
Intra	PTPN6	P29350	FCGR2B	Homo sapiens	P31994	SELDI Chip	8577729
Intra	PTPN6	P29350	FCGR2B	Homo sapiens	P31994	Affinity Chrom	9148918
Intra	PTPN6	P29350	ROS1	Homo sapiens	P08922	Pull Down	11266449
Intra	PTPN6	P29350	ROS1	Homo sapiens	P08922	CoIP	11266449
Intra	PTPN6	P29350	FHL3	Homo sapiens	Q13643	Y2H Array	25416956
Intra	PTPN6	P29350	CASP8	Homo sapiens	Q14790	Anti Bait CoIP	18086677
Intra	PTPN6	P29350	CASP8	Homo sapiens	Q14790	Anti Tag CoIP	18086677
Intra	PTPN6	P29350	KIR2DL3	Homo sapiens	P43628	Pull Down	8691154
Intra	PTPN6	P29350	KIR2DL3	Homo sapiens	P43628	Pull Down	8648092
Intra	PTPN6	P29350	KIR2DL3	Homo sapiens	P43628	Affinity Chrom	9148918
Intra	PTPN6	P29350	KIR2DL1	Homo sapiens	P43626	CoIP	8691146
Intra	PTPN6	P29350	KIR2DL1	Homo sapiens	P43626	Pull Down	8691146
Intra	PTPN6	P29350	PILRA	Homo sapiens	Q9UKJ1	SPR	10660620
Intra	PTPN6	P29350	PILRA	Homo sapiens	Q9UKJ1	Y2H	10660620
Intra	PTPN6	P29350	LAIR1	Homo sapiens	Q6GTX8	Pull Down	10764762
Intra	PTPN6	P29350	LAIR1	Homo sapiens	Q6GTX8	Y2H	10660620
Intra	PTPN6	P29350	LAIR1	Homo sapiens	Q6GTX8	CoIP	10764762
Cross	PTPN6	P29350	tir	Escherichia coli O127:H6	B7UM99	Pull Down	23001144
Cross	PTPN6	P29350	Ppp1r9b	Rattus norvegicus	O35274	Anti Tag CoIP	25785436

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPN6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71141	SHP-1 Protein, Human (His)	AAH02523.1 (K243-I541)	≥ 95%, as determined by reducing SDS-PAGE.

PTPN6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81307	SHP1 Antibody (YA1044)	WB, IP	Human
HY-P81307A	SHP1 Antibody (YA1045)	WB, IHC-P, ICC/IF, FC	Human
HY-P81307AA	SHP1 Antibody (YA1045)(PBS only)	WB, IHC-P, ICC/IF, FC	Human
HY-P84244	SHP1 Antibody (YA3941)	ICC/IF, FC, ELISA	Human
HY-P84244A	SHP1 Antibody (YA3941)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Neutrophilic Dermatosis, Acute Febrile	Sweet Syndrome Acute Febrile Neutrophilic Dermatosis Ss AFND Pyrin-Associated Autoinflammatory Disease PAAND Gomm-Button Disease Sweet'S Syndrome Gomm Button Disease Sweets Syndrome Acromelic Frontonasal Dysostosis Sweet Disease
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Erythrocytosis, Familial, 1	ECYT1 Pfcp Primary Familial And Congenital Polycythemia Familial Erythrocytosis 1 Familial Erythrocytosis Polycythemia, Primary Familial And Congenital Autosomal Dominant Benign Erythrocytosis Familial Erythrocytosis Type 1 Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation Congenital Polycythemia Due To Erythropoietin Receptor Mutation Primary Congenital Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Autosomal Dominant Benign Erythrocytosis, Somatic Autosomal Dominant Familial Erythrocytosis-1 Erythrocytosis Autosomal Dominant Benign Familial Primary Polycythemia Familial Erythrocytosis, 1 Erythrocytosis, Familial, Type 1
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-136657	SC-43		99.01%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119024	BCI-137		99.84%	Unkown
HY-N4150	Quercetagitrin	Inhibitor	98.33%	Unkown
HY-RS11429	PTPN6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17306	Ptpn6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23761	Ptpn6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTPN6	VGNC	VGNC:69166
Rattus norvegicus	PTPN6	RGD	RGD:620660
Mus musculus	PTPN6	MGD	MGI:96055
Macaca mulatta	PTPN6	VGNC	VGNC:76607
Bos taurus	PTPN6	VGNC	VGNC:33541
Canis familiaris	PTPN6	VGNC	VGNC:45179
Others	PTPN6	NCBI