THEMIS - thymocyte selection associated Gene

Homo sapiens

Also known as GASP; SPOT; TSEPA; C6orf190; C6orf207

Gene ID: 387357 | Gene type: protein coding

About THEMIS

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,696,628-127,918,595 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 167 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 2.2), appendix (RPKM 1.1) and 12 other tissues.

Summary

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

THEMIS Products(7)

mRNA	Protein	Name
NM_001010923.3	NP_001010923.1	protein THEMIS isoform 2
NM_001164685.2	NP_001158157.1	protein THEMIS isoform 1
NM_001164687.2	NP_001158159.1	protein THEMIS isoform 3
NM_001318531.1	NP_001305460.1	protein THEMIS isoform 4
NM_001394520.1	NP_001381449.1	protein THEMIS isoform 5
NM_001394521.1	NP_001381450.1	protein THEMIS isoform 6
NM_001394522.1	NP_001381451.1	protein THEMIS isoform 4

THEMIS Protein Structure

CABIT

0
100
200
300
400
500
600
641 a.a.

Protein Preferred Names

Protein Names

protein THEMIS

GRB2-associated protein

Related Diseases

Diseases

Alias

Developmental Coordination Disorder

Motor Skills Disorders

Lynch Syndrome I

Lynch Syndrome 1	Colorectal Cancer, Hereditary Nonpolyposis, Type 1
HNPCC1	Fcc1
Lynch Syndrome Ii	Colon Cancer, Familial Nonpolyposis, Type 1
Coca1	Familial Nonpolyposis Colon Cancer Type 1
Hereditary Nonpolyposis Colorectal Cancer Type 1	Hereditary Non-Polyposis Colorectal Cancer 1
Hereditary Non-Polyposis Colorectal Cancer 3	Hnpcc3
Lynch Cancer Family Syndrome	Lynch Syndrome
Lynch Syndrome Type I	Lynch Syndrome Type Ii
Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1	Hereditary Nonpolyposis Colorectal Cancer
Colorectal Cancer, Hereditary Nonpolyposis, Type 3	Hereditary Non-Polyposis Colon Cancer Type 2

Diamond-Blackfan Anemia 1

Aase Syndrome	DBA1
Erythrogenesis Imperfecta	Aase-Smith Syndrome Ii
Dba	Blackfan-Diamond Syndrome
Bds	Anemia, Congenital Hypoplastic, Of Blackfan And Diamond
Anemia, Congenital Erythroid Hypoplastic	Red Cell Aplasia, Pure, Hereditary
Aregenerative Anemia, Chronic Congenital	Rps19-Related Diamond-Blackfan Anemia
Chronic Congenital Aregenerative Anemia	Congenital Erythroid Hypoplastic Anemia
Congenital Hypoplastic Anemia Of Blackfan And Diamond	Pure Hereditary Red Cell Aplasia
Anemia, Diamond-Blackfan, Type 1	Anemia, Diamond-Blackfan
Aase Smith Syndrome 2	Familial Hypoplastic Anaemia With Malformations
Constitutional Pure Red Cell Aplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14488	THEMIS Human Pre-designed siRNA Set A		/	Unkown
HY-RS14489	THEMIS2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	THEMIS	MGD	MGI:2443552
Felis catus	THEMIS	VGNC	VGNC:66161
Macaca mulatta	THEMIS	VGNC	VGNC:83496
Bos taurus	THEMIS	VGNC	VGNC:35835
Rattus norvegicus	THEMIS	RGD	RGD:1560849
Canis familiaris	THEMIS	VGNC	VGNC:47343

Name
Email *

	Sorry, but the email address you supplied was invalid.