LAIR1 - leukocyte associated immunoglobulin like receptor 1 Gene

Homo sapiens

Also known as CD305; LAIR-1

Gene ID: 3903 | Gene type: protein coding

About LAIR1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,351,384-54,376,088 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele and 66 orthologues. Broad expression in bone marrow (RPKM 19.6), appendix (RPKM 16.8) and 17 other tissues.

Summary

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine Phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

LAIR1 Products(6)

mRNA	Protein	Name
NM_001289023.3	NP_001275952.2	leukocyte-associated immunoglobulin-like receptor 1 isoform c precursor
NM_001289025.3	NP_001275954.2	leukocyte-associated immunoglobulin-like receptor 1 isoform e precursor
NM_001289026.3	NP_001275955.2	leukocyte-associated immunoglobulin-like receptor 1 isoform f
NM_001289027.3	NP_001275956.2	leukocyte-associated immunoglobulin-like receptor 1 isoform g
NM_002287.6	NP_002278.2	leukocyte-associated immunoglobulin-like receptor 1 isoform a precursor
NM_021706.5	NP_068352.2	leukocyte-associated immunoglobulin-like receptor 1 isoform b precursor

LAIR1 Protein Structure

Ig_2

0
100
200
287 a.a.

Protein Preferred Names

Protein Names

leukocyte-associated immunoglobulin-like receptor 1

immunoglobulin heavy chain variable region

Recombinant LAIR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72390	LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His)	Q6GTX8 (Q22-H163)	≥95%
HY-P72529	LAIR1 Protein, Human (HEK293, His)	Q6GTX8 (Q22-H163)	≥95%
HY-P74784	LAIR1 Protein, Human (144a.a, HEK293, hFc)	Q6GTX8 (Q22-Y165)	≥95%
HY-P74785	LAIR1 Protein, Human (Biotinylated, 165a.a, HEK293, His-Avi)	Q6GTX8 (M1-Y165)	≥95%
HY-P74786	LAIR1 Protein, Human (Biotinylated, 144a.a, HEK293, His)	Q6GTX8 (Q22-Y165)	≥95%
HY-P74787	LAIR1 Protein, Human (165a.a, HEK293, His)	Q6GTX8 (M1-Y165)	≥95%
HY-P78476	LAIR1 Protein, Human (HEK293, His-Avi)	Q6GTX8 (Q22-H163)	≥95%

Related Diseases

Diseases

Alias

Chronic Active Epstein-Barr Virus Infection

Caebv Infection	Cebv
Chronic Active Epstein-Barr Disease

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07494	LAIR1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LAIR1	MGD	MGI:105492
Felis catus	LAIR1	VGNC	VGNC:109515
Rattus norvegicus	LAIR1	RGD	RGD:1560048
Bos taurus	LAIR1	VGNC	VGNC:109390
Macaca mulatta	LAIR1	NCBI
Others	LAIR1	NCBI

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