LAIR1 - leukocyte associated immunoglobulin like receptor 1 Gene

Also Known as CD305; LAIR-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3903

About LAIR1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,351,384-54,376,088 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele and 66 orthologues. Broad expression in bone marrow (RPKM 19.6), appendix (RPKM 16.8) and 17 other tissues.

Summary

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine Phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

LAIR1 Products (6)

mRNA Protein Name
NM_001289023.3 NP_001275952.2 leukocyte-associated immunoglobulin-like receptor 1 isoform c precursor
NM_001289025.3 NP_001275954.2 leukocyte-associated immunoglobulin-like receptor 1 isoform e precursor
NM_001289026.3 NP_001275955.2 leukocyte-associated immunoglobulin-like receptor 1 isoform f
NM_001289027.3 NP_001275956.2 leukocyte-associated immunoglobulin-like receptor 1 isoform g
NM_002287.6 NP_002278.2 leukocyte-associated immunoglobulin-like receptor 1 isoform a precursor
NM_021706.5 NP_068352.2 leukocyte-associated immunoglobulin-like receptor 1 isoform b precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10660620 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAIR1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (29 - 120)

  • 0
  • 100
  • 200
  • 287 a.a.
Protein Preferred Names Protein Names

leukocyte-associated immunoglobulin-like receptor 1

  • immunoglobulin heavy chain variable region

LAIR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LAIR1 Q6GTX8 PTPN6 Homo sapiens P29350
Pull Down
10764762
Intra
LAIR1 Q6GTX8 PTPN6 Homo sapiens P29350
CoIP
10764762
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LAIR1 Proteins

Cat. No. Product Name Accession Purity
HY-P72390 LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His) AAH27899.1 (Q22-H163) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72529 LAIR1 Protein, Human (HEK293, His) AAH27899.1 (Q22-H163) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74784 LAIR1 Protein, Human (HEK293, hFc) Q6GTX8-1 (Q22-H163) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74786 LAIR1 Protein, Human (Biotinylated, HEK293, His) Q6GTX8-1 (Q22-H163) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78476 LAIR1 Protein, Human (HEK293, His-Avi) Q6GTX8-1 (Q22-H163) ≥ 95%, as determined by Bis-Tris PAGE.

LAIR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86938 LAIR1 Antibody (YA6631) WB, IHC-P Human

Related Diseases

Diseases Alias
Chronic Active Epstein-Barr Virus Infection

  • Caebv Infection

  • Cebv

  • Chronic Active Epstein-Barr Disease
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991193 NGM-438 Activator 99.74% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07494 LAIR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17254 Lair1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23708 Lair1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992255 Anti-LAIR1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LAIR1 MGD MGI:105492
Felis catus LAIR1 VGNC VGNC:109515
Rattus norvegicus LAIR1 RGD RGD:1560048
Bos taurus LAIR1 VGNC VGNC:109390
Others LAIR1 NCBI