LAIR1 Antibody (YA6631)
(Synonyms: 5133400O11Rik antibody; CD305 antibody; D7Bwg0421e antibody; hLAIR1 antibody; LAIR 1 antibody; LAIR-1 antibody; LAIR1 antibody; LAIR1 protein antibody; LAIR1_HUMAN antibody; Leukocyte associated Ig like receptor 1 antibody; 5133400O11Rik antibody; CD305 antibody; D7Bwg0421e antibody; hLAIR1 antibody; LAIR 1 antibody; LAIR-1 antibody; LAIR1 antibody; LAIR1 protein antibody; LAIR1_HUMAN antibody; Leukocyte associated Ig like receptor 1 antibody; Leukocyte associated immunoglobulin like receptor 1 antibody; Leukocyte-associated immunoglobulin-like receptor 1 antibody; )LAIR1 Antibody (YA6631) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LAIR1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:2000 | 1:200 |
Product Details
LAIR1 Antibody (YA6631) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LAIR1.
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Host Mouse
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 40-45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 32 kDa
Recombinant protein within human LAIR1 aa 166-287 / 287.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection
Induction: By T-cell receptor stimulation in a process that requires p38 MAP kinase and ERK signaling -
Isoforms & Post-Translational Modification
The Q6GTX8 has four isomers: Q6GTX8-1: 31469 Da (predicted); Q6GTX8-2: 29911 Da (predicted); Q6GTX8-3: 29782 Da (predicted); Q6GTX8-4: 23106 Da (predicted).
Phosphorylation at Tyr-251 and Tyr-281 activates it丨N-glycosylated -
Subunit
Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11
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SwissProt ID
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Synonyms
5133400O11Rik antibody; CD305 antibody; D7Bwg0421e antibody; hLAIR1 antibody; LAIR 1 antibody; LAIR-1 antibody; LAIR1 antibody; LAIR1 protein antibody; LAIR1_HUMAN antibody; Leukocyte associated Ig like receptor 1 antibody; 5133400O11Rik antibody; CD305 antibody; D7Bwg0421e antibody; hLAIR1 antibody; LAIR 1 antibody; LAIR-1 antibody; LAIR1 antibody; LAIR1 protein antibody; LAIR1_HUMAN antibody; Leukocyte associated Ig like receptor 1 antibody; Leukocyte associated immunoglobulin like receptor 1 antibody; Leukocyte-associated immunoglobulin-like receptor 1 antibody;
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