LCORL - ligand dependent nuclear receptor corepressor like Gene

Also Known as MLR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 254251

About LCORL

Cytogenetic location: 4p15.31 Genomic coordinates (GRCh38): 4:17,841,187-18,021,875 (from NCBI)

This gene has 15 transcripts (splice variants), 96 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 2.1), small intestine (RPKM 1.8) and 25 other tissues.

Summary

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

LCORL Products (10)

mRNA	Protein	Name
NM_001166139.2	NP_001159611.1	ligand-dependent nuclear receptor corepressor-like protein isoform 1
NM_001365658.1	NP_001352587.1	ligand-dependent nuclear receptor corepressor-like protein isoform 3
NM_001365659.1	NP_001352588.1	ligand-dependent nuclear receptor corepressor-like protein isoform 3
NM_001365660.1	NP_001352589.1	ligand-dependent nuclear receptor corepressor-like protein isoform 4
NM_001365661.1	NP_001352590.1	ligand-dependent nuclear receptor corepressor-like protein isoform 5
NM_001365662.1	NP_001352591.1	ligand-dependent nuclear receptor corepressor-like protein isoform 6
NM_001365663.1	NP_001352592.1	ligand-dependent nuclear receptor corepressor-like protein isoform 7
NM_001365665.1	NP_001352594.1	ligand-dependent nuclear receptor corepressor-like protein isoform 8
NM_001394446.1	NP_001381375.1	ligand-dependent nuclear receptor corepressor-like protein isoform 9
NM_153686.8	NP_710153.2	ligand-dependent nuclear receptor corepressor-like protein isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables histone methyltransferase binding	IPI IPI: Inferred from physical interaction	29628311	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21900206	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCORL Protein Structure

HTH_psq

0
100
200
300
400
500
602 a.a.

Protein Preferred Names	Protein Names
ligand-dependent nuclear receptor corepressor-like protein	LCOR-like protein

LCORL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LCORL	Q8N3X6	MAGEA6	Homo sapiens	P43360	Y2H Array	25416956
Intra	LCORL	Q8N3X6	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
Intra	LCORL	Q8N3X6	CTBP1	Homo sapiens	Q13363	TAP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Croup	Acute Obstructive Laryngitis Laryngotracheobronchitis Acute Laryngotracheobronchitis Croup Syndrome Acute Laryngitis With Obstruction Obstructive Laryngitis Obstructive Laryngitis Nos Obstructive Laryngotracheitis Nos
Acromesomelic Dysplasia 2b	Fibular Hypoplasia And Complex Brachydactyly Du Pan Syndrome AMD2B Dupans Acromesomelic Dysplasia-2b Fibular Aplasia-Complex Brachydactyly Syndrome
Acromesomelic Dysplasia	Acromesomelic Dwarfism Dysplasia, Acromesomelic Acromesomelic Dysplasia Hunter-Thompson Type
Osteochondrosis	Osteochondritis Apophysitis Epiphysitis Osteochondritis Juvenilis Epiphyseal Necrosis Juvenile Osteochondrosis Of Tibial Tubercle

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07562	LCORL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LCORL	RGD	RGD:1561241
Felis catus	LCORL	VGNC	VGNC:78520
Mus musculus	LCORL	MGD	MGI:2651932
Canis familiaris	LCORL	VGNC	VGNC:59023
Macaca mulatta	LCORL	VGNC	VGNC:106624
Bos taurus	LCORL	VGNC	VGNC:30816
Others	LCORL	NCBI