SYCE1 - synaptonemal complex central element protein 1 Gene

Homo sapiens

Also known as CT76; POF12; SPGF15; C10orf94

Gene ID: 93426 | Gene type: protein coding

About SYCE1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,553,899-133,568,291 (from NCBI)

This gene has 5 transcripts (splice variants), 117 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in testis (RPKM 31.6), placenta (RPKM 4.3) and 1 other tissue.

Summary

This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

SYCE1 Products(3)

mRNA	Protein	Name
NM_001143763.2	NP_001137235.1	synaptonemal complex central element protein 1 isoform 3
NM_001143764.3	NP_001137236.1	synaptonemal complex central element protein 1 isoform 4
NM_130784.4	NP_570140.1	synaptonemal complex central element protein 1 isoform 1

SYCE1 Protein Structure

SYCE1

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

synaptonemal complex central element protein 1

cancer/testis antigen 76

Related Diseases

Diseases

Alias

Spermatogenic Failure 15

SPGF15

Spermatogenic Failure, 15

Premature Ovarian Failure 12

POF12

Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

46 Xx Gonadal Dysgenesis

Ovarian Dysgenesis	Gonadal Dysgenesis, 46,Xx
Dysgenesis, Ovarian

Spermatogenic Failure 10

SPGF10

Spermatogenic Failure With Defective Sperm Annulus

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa	Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna
SPGF5	Macrocephalic Sperm Head Syndrome
Male Infertility Due To Macrozoospermia	Infertility Associated With Multitailed Spermatozoa And Excessive Dna
Macrozoospermia	Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa
Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid	Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Multiple Synostoses Syndrome

Symphalangism-Brachydactyly Syndrome	Deafness-Hermann Type Symphalangism Syndrome
Facio-Audio-Symphalangism	Hearing Loss-Hermann Type Symphalangism Syndrome
Wl Syndrome	Multiple Synostosis Syndrome

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14068	SYCE1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SYCE1	VGNC	VGNC:35504
Rattus norvegicus	SYCE1	RGD	RGD:1559853
Felis catus	SYCE1	VGNC	VGNC:97651
Canis familiaris	SYCE1	VGNC	VGNC:47014
Mus musculus	SYCE1	MGD	MGI:1921325

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