ALOX5 - arachidonate 5-lipoxygenase Gene

Also Known as 5-LO; 5LPG; LOG5; 5-LOX

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 240

About ALOX5

Cytogenetic location: 10q11.21 Genomic coordinates (GRCh38): 10:45,374,216-45,446,117 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 221 orthologues, 5 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 35.1), lung (RPKM 26.8) and 15 other tissues.

Summary

This gene encodes a member of the Lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

ALOX5 Products (13)

mRNA	Protein	Name
NM_000698.5	NP_000689.1	polyunsaturated fatty acid 5-lipoxygenase isoform 1
XM_047424934.1	XP_047280890.1	polyunsaturated fatty acid 5-lipoxygenase isoform X1
NM_001256154.3	NP_001243083.1	polyunsaturated fatty acid 5-lipoxygenase isoform 3
XM_047424936.1	XP_047280892.1	polyunsaturated fatty acid 5-lipoxygenase isoform X2
NM_001320861.2	NP_001307790.1	polyunsaturated fatty acid 5-lipoxygenase isoform 4
NM_001320862.2	NP_001307791.1	polyunsaturated fatty acid 5-lipoxygenase isoform 5
XM_047424937.1	XP_047280893.1	polyunsaturated fatty acid 5-lipoxygenase isoform X3
NM_001256153.3	NP_001243082.1	polyunsaturated fatty acid 5-lipoxygenase isoform 2
NM_000698.5	NP_000689.1	polyunsaturated fatty acid 5-lipoxygenase isoform 1
NM_001256153.3	NP_001243082.1	polyunsaturated fatty acid 5-lipoxygenase isoform 2
NM_001256154.3	NP_001243083.1	polyunsaturated fatty acid 5-lipoxygenase isoform 3
NM_001320861.2	NP_001307790.1	polyunsaturated fatty acid 5-lipoxygenase isoform 4
NM_001320862.2	NP_001307791.1	polyunsaturated fatty acid 5-lipoxygenase isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables arachidonate 5-lipoxygenase activity	IDA IDA: Inferred from direct assay	8615788	GOA
enables iron ion binding	IDA IDA: Inferred from direct assay	21233389	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7929073	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in leukocyte chemotaxis involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	17114001	GOA
involved in leukotriene A4 biosynthetic process	IDA IDA: Inferred from direct assay	24282679	GOA
involved in leukotriene A4 biosynthetic process	IMP IMP: Inferred from mutant phenotype	31664810	GOA
involved in leukotriene biosynthetic process	IDA IDA: Inferred from direct assay	21233389	GOA
involved in lipoxin biosynthetic process	IMP IMP: Inferred from mutant phenotype	31664810	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	21206090	GOA
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	17114001	GOA
involved in regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	26210919	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	19233132	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	19233132	GOA
located in nuclear envelope lumen	IDA IDA: Inferred from direct assay	8245774	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	19233132	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	8245774	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19022417	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALOX5 Protein Structure

PLAT

Lipoxygenase

0
200
400
600
674 a.a.

Protein Preferred Names	Protein Names
polyunsaturated fatty acid 5-lipoxygenase	LOX-5 arachidonic acid 5-lipoxygenase leukotriene A4 synthase

ALOX5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ALOX5	P09917	NUTM1	Homo sapiens	Q86Y26	Y2H Prey Pooling	25416956
Intra	ALOX5	P09917	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	ALOX5	P09917	HHIPL2	Homo sapiens	Q6UWX4	Y2H Array	25910212
Intra	ALOX5	P09917	HHIPL2	Homo sapiens	Q6UWX4	Y2H Array	25416956
Intra	ALOX5	P09917	HHIPL2	Homo sapiens	Q6UWX4	Validated Y2H	25910212
Intra	ALOX5	P09917	HHIPL2	Homo sapiens	Q6UWX4	Y2H Bait-Prey Pool	25910212
Intra	ALOX5	P09917	LCN1	Homo sapiens	P31025	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	LCN1	Homo sapiens	P31025	Validated Y2H	32296183
Intra	ALOX5	P09917	LCN1	Homo sapiens	P31025	Y2H Array	32296183
Intra	ALOX5	P09917	CEP63	Homo sapiens	Q96MT8-3	Y2H Array	25910212
Intra	ALOX5	P09917	CEP63	Homo sapiens	Q96MT8-3	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	CEP63	Homo sapiens	Q96MT8-3	Validated Y2H	32296183
Intra	ALOX5	P09917	CEP63	Homo sapiens	Q96MT8-3	Y2H Array	32296183
Intra	ALOX5	P09917	CEP63	Homo sapiens	Q96MT8-3	Y2H Bait-Prey Pool	25910212
Intra	ALOX5	P09917	CEP63	Homo sapiens	Q96MT8-3	Validated Y2H	25910212
Intra	ALOX5	P09917	CEP57L1	Homo sapiens	Q6P2R3	Y2H Array	25910212
Intra	ALOX5	P09917	CEP57L1	Homo sapiens	Q6P2R3	Validated Y2H	25910212
Intra	ALOX5	P09917	CEP57L1	Homo sapiens	Q6P2R3	Y2H Bait-Prey Pool	25910212
Intra	ALOX5	P09917	HSD17B1	Homo sapiens	P14061	Validated Y2H	32296183
Intra	ALOX5	P09917	HSD17B1	Homo sapiens	P14061	Y2H Array	32296183
Intra	ALOX5	P09917	HSD17B1	Homo sapiens	P14061	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	C10orf67	Homo sapiens	Q8IYJ2-2	Y2H Array	32296183
Intra	ALOX5	P09917	C10orf67	Homo sapiens	Q8IYJ2-2	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	C10orf67	Homo sapiens	Q8IYJ2-2	Validated Y2H	32296183
Intra	ALOX5	P09917	FGR	Homo sapiens	P09769	Protein Kinase Assay	24860872
Intra	ALOX5	P09917	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	ALOX5	P09917	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ALOX5	P09917	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	OOEP	Homo sapiens	A6NGQ2	Y2H Array	32296183
Intra	ALOX5	P09917	OOEP	Homo sapiens	A6NGQ2	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	25416956
Intra	ALOX5	P09917	MEOX1	Homo sapiens	P50221	Y2H Array	25416956
Intra	ALOX5	P09917	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	ALOX5	P09917	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	ALOX5	P09917	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
Intra	ALOX5	P09917	TBC1D7	Homo sapiens	Q9P0N9	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	TBC1D7	Homo sapiens	Q9P0N9	Y2H Array	32296183
Intra	ALOX5	P09917	PRKACA	Homo sapiens	P17612	Protein Kinase Assay	24860872
Intra	ALOX5	P09917	YES1	Homo sapiens	P07947	Protein Kinase Assay	24860872
Intra	ALOX5	P09917	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ALOX5	P09917	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ALOX5	P09917	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ALOX5	P09917	SYCE1	Homo sapiens	Q8N0S2	Y2H Array	25416956
Intra	ALOX5	P09917	SYCE1	Homo sapiens	Q8N0S2	Y2H Array	25910212
Intra	ALOX5	P09917	SYCE1	Homo sapiens	Q8N0S2	Y2H Bait-Prey Pool	25910212
Intra	ALOX5	P09917	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25910212
Intra	ALOX5	P09917	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25416956
Intra	ALOX5	P09917	GATC	Homo sapiens	O43716	Y2H Array	32296183
Intra	ALOX5	P09917	GATC	Homo sapiens	O43716	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	CEP63	Homo sapiens	Q96MT8	Y2H Prey Pooling	25416956
Intra	ALOX5	P09917	CEP63	Homo sapiens	Q96MT8	Y2H Array	25416956
Intra	ALOX5	P09917	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Bait-Prey Pool	25910212
Intra	ALOX5	P09917	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	32296183
Intra	ALOX5	P09917	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	25910212
Intra	ALOX5	P09917	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	32296183
Intra	ALOX5	P09917	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	25416956
Intra	ALOX5	P09917	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	25910212
Intra	ALOX5	P09917	CCDC174	Homo sapiens	Q6PII3	Validated Y2H	32296183
Intra	ALOX5	P09917	CCDC174	Homo sapiens	Q6PII3	Y2H Array	32296183
Intra	ALOX5	P09917	CCDC174	Homo sapiens	Q6PII3	Y2H Prey Pooling	32296183
Intra	ALOX5	P09917	COTL1	Homo sapiens	Q14019	Y2H	11297527
Intra	ALOX5	P09917	COTL1	Homo sapiens	Q14019	Pull Down	11297527
Intra	ALOX5	P09917	COTL1	Homo sapiens	Q14019	CoIP	11297527

Cross: Cross-species interaction Intra: Intraspecies interaction

ALOX5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82192	5 Lipoxygenase Antibody (YA1937)	WB, IHC-F, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Nasal Cavity Disease	Disorder Of Nasal Cavity
Exercise-Induced Bronchoconstriction	Exercise-Induced Asthma Asthma Exercise-Induced
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Small Intestine Leiomyosarcoma	Leiomyosarcoma Of The Small Bowel Smooth Muscle Connective Tissue Tumor Leiomyosarcoma Of Small Intestine
Proteasome-Associated Autoinflammatory Syndrome 1	Jmp Syndrome Nakajo-Nishimura Syndrome Nkjo Autoinflammation, Lipodystrophy, And Dermatosis Syndrome Proteasome-Associated Autoinflammatory Syndrome 1 And Digenic Forms Nakajo Syndrome PRAAS1 Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature Syndrome Candle Joint Contractures, Muscular Atrophy, Microcytic Anemia, And Panniculitis-Induced Lipodystrophy Aldd Joint Contractures - Muscle Atrophy - Microcytic Anemia - Panniculitis-Induced Lipodystrophy Nakajo Nishimura Syndrome Amyotrophy Fat Tissue Anomaly Japanese Autoinflammatory Syndrome With Lipodystrophy Jasl Joint Contractures Muscular Atrophy Microcytic Anemia And Panniculitis-Induced Lipodystrophy Nns Nodular Erythema With Digital Changes Secondary Hypertrophic Osteoperiostosis With Pernio Inflammation
Cone-Rod Dystrophy 17	CORD17
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Psoriasis
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases Cardiovascular Disease
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Arthus Reaction	Arthus Phenomenon Arthus Type Urticaria
Glomerulonephritis	Bright'S Disease
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Allergic Rhinitis	Hay Fever Allergic Rhinitis, Susceptibility To ALRH Atopic Rhinitis Seasonal Allergic Rhinitis Non-Seasonal Allergic Rhinitis Perenial Allergic Rhinitis Pollenosis Rhinitis Allergic Seasonal Rhinitis, Allergic, Perennial Allergic Rhinitis, Cause Unspecified Pollinosis Pollen Allergy Allergy Nos Due To Pollen Summer Catarrh Other Seasonal Allergic Rhinitis
Panniculitis	Nodular Panniculitis
Acute Laryngopharyngitis	Pharyngolaryngitis Laryngopharyngitis Hypopharyngitis
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Ichthyosis, Congenital, Autosomal Recessive 3	Autosomal Recessive Congenital Ichthyosis 3 ARCI3 Lamellar Ichthyosis 5 Collodion Baby, Self-Healing Ichthyosis, Lamellar, 5, Formerly Li5, Formerly Li5 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 3
Aspirin-Induced Respiratory Disease	Aspirin-Sensitive Asthma
Chronic Urticaria	Urticaria Chronic Chronic Spontaneous Urticaria Chronic Ordinary Urticaria
Angioedema	Angioneurotic Oedema Quincke'S Edema Angioneurotic Edema Giant Urticaria
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Persistent Mild Asthma
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Pleurisy
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150109A	Purinostat	Inhibitor	98.04%	Unkown
HY-RS00620	ALOX5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00625	Alox5ap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175634	ALOX5 stabilizer-1		/	Unkown
HY-175634A	ALOX5 stabilizer-1 TFA		/	Unkown
HY-E71028	5-Lipoxygenase, Human		/	Unkown
HY-RS00621	Alox5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00622	Alox5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00623	ALOX5AP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00624	Alox5ap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ALOX5	VGNC	VGNC:59757
Rattus norvegicus	ALOX5	RGD	RGD:2096
Macaca mulatta	ALOX5	VGNC	VGNC:69798
Bos taurus	ALOX5	VGNC	VGNC:25844
Mus musculus	ALOX5	MGD	MGI:87999
Canis familiaris	ALOX5	VGNC	VGNC:37813
Others	ALOX5	NCBI