GATC - glutamyl-tRNA amidotransferase subunit C Gene

Also Known as 15E1.2; COXPD42

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283459

About GATC

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,446,444-120,463,749 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 15.5), lymph node (RPKM 14.0) and 25 other tissues.

Summary

Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined Oxidative Phosphorylation deficiency 42. [provided by Alliance of Genome Resources, Apr 2022]

GATC Products (1)

mRNA Protein Name
NM_176818.3 NP_789788.1 glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19805282 GOA
Biological Process GO Annotation Evidence References Source
involved in glutaminyl-tRNAGln biosynthesis via transamidation IDA
IDA: Inferred from direct assay
19805282 GOA
involved in mitochondrial translation IMP
IMP: Inferred from mutant phenotype
19805282 GOA
Cellular Component GO Annotation Evidence References Source
part of glutamyl-tRNA(Gln) amidotransferase complex IDA
IDA: Inferred from direct assay
19805282 GOA
part of glutamyl-tRNA(Gln) amidotransferase complex IPI
IPI: Inferred from physical interaction
19805282 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
19805282 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GATC Protein Structure

Glu-tRNAGln

Glu-tRNAGln: Glu-tRNAGln amidotransferase C subunit (52 - 116)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

  • glu-AdT subunit C

GATC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GATC O43716 CTAG1A Homo sapiens P78358
Validated Y2H
32296183
Intra
GATC O43716 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
GATC O43716 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
GATC O43716 TOMM20L Homo sapiens Q6UXN7
Validated Y2H
32296183
Intra
GATC O43716 TOMM20L Homo sapiens Q6UXN7
Y2H Array
32296183
Intra
GATC O43716 TOMM20L Homo sapiens Q6UXN7
Y2H Prey Pooling
32296183
Intra
GATC O43716 SRSF11 Homo sapiens Q05519-2
Y2H Prey Pooling
32296183
Intra
GATC O43716 SRSF11 Homo sapiens Q05519-2
Validated Y2H
32296183
Intra
GATC O43716 SRSF11 Homo sapiens Q05519-2
Y2H Array
32296183
Intra
GATC O43716 QRSL1 Homo sapiens Q9H0R6
Anti Tag CoIP
33961781
Intra
GATC O43716 QRSL1 Homo sapiens Q9H0R6
Anti Tag CoIP
28514442
Intra
GATC O43716 QRSL1 Homo sapiens Q9H0R6
GMS
19805282
Intra
GATC O43716 ALOX5 Homo sapiens P09917
Y2H Prey Pooling
32296183
Intra
GATC O43716 ALOX5 Homo sapiens P09917
Validated Y2H
32296183
Intra
GATC O43716 ALOX5 Homo sapiens P09917
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 42

  • COXPD42
Combined Oxidative Phosphorylation Deficiency
Wound Botulism

  • Cutaneous Infectious Botulism

  • Cutaneous Toxin-Mediated Botulism

  • Inoculation Botulism

  • Skin Infectious Botulism

  • Skin Toxin-Mediated Botulism
Lactic Acidosis

  • Acidosis, Lactic

  • Acidosis Lactic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148511 Vidutolimod 93.85% Phase 3

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150741 ODN 2216 98.57% Unkown
HY-RS05299 GATC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GATC MGD MGI:1923776
Rattus norvegicus GATC RGD RGD:1309698
Others GATC NCBI