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Cat. No.: HY-175634A

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ALOX5 stabilizer-1 TFA

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ALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a K_d of 7.26 μM. ALOX5 stabilizer-1 TFA inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 TFA induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 TFA can used for the study of non-small cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

Formula: C₃₄H₃₃F₃N₄O₇
Molecular Weight:666.64

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ALOX5 stabilizer-1 TFA Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Lipoxygenase Isoforms :

All STAT Isoforms :

In Vitro

ALOX5 stabilizer-1 (Compound 10d) (72 h) TFA inhibits NCI-H820 cell proliferation with an IC₅₀ of 0.11 μM and shows weaker toxicity against 3T3 cells with an IC₅₀ of 0.48 μM ^[1].
ALOX5 stabilizer-1 (0-0.2 μM, 10 d) TFA inhibits colony formation of with NCI-H820 cells a dose-dependent manner^[1].
ALOX5 stabilizer-1 (0-0.2 μM, 48 h) TFA inhibits NCI-H820 cell migration and induces cell apoptosis^[1].
ALOX5 stabilizer-1 (0-0.2 μM, 48 h) TFA directly targets ALOX5 protein and enhances protein stability, then inhibites β-catenin protein levels and eventually suppressed STAT3 signal pathway in NCI-H820 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 666.64
Formula C₃₄H₃₃F₃N₄O₇
SMILES

C[C@@]12CC/C=C(CN3C=C(N=N3)COC4=CC=C(C=C4)C(/C=C/C5=CC=CN=C5)=O)\CC[C@@H]6[C@H](OC(C6=C)=O)[C@H]1O2.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bai Y, et al. Design, synthesis and bioactivity evaluation of parthenolide-chalcone hybrids as potential anti-lung cancer agents. Bioorg Chem. 2025 Jul 26;164:108808. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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ALOX5 stabilizer-1 TFA

Apoptosis Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Metabolism/Protease Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Macrocyclic Compound Library

Ferroptosis Compound Library

Cytoskeleton Compound Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Lipid Metabolism Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Antihypertensive Compound Library

Metabolic Enzyme Compound Library

Cell Death Library

Extracellular Vesicles (EVs) Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Fibrosis Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

All Lipoxygenase Isoforms

All STAT Isoforms