ALOX5 stabilizer-1 TFA 

ALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a K_d of 7.26 μM. ALOX5 stabilizer-1 TFA inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 TFA induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 TFA can used for the study of non-small cell lung cancer (NSCLC)^[1].

ALOX5 stabilizer-1 (Compound 10d) (72 h) TFA inhibits NCI-H820 cell proliferation with an IC₅₀ of 0.11 μM and shows weaker toxicity against 3T3 cells with an IC₅₀ of 0.48 μM ^[1].
ALOX5 stabilizer-1 (0-0.2 μM, 10 d) TFA inhibits colony formation of with NCI-H820 cells a dose-dependent manner^[1].
ALOX5 stabilizer-1 (0-0.2 μM, 48 h) TFA inhibits NCI-H820 cell migration and induces cell apoptosis^[1].
ALOX5 stabilizer-1 (0-0.2 μM, 48 h) TFA directly targets ALOX5 protein and enhances protein stability, then inhibites β-catenin protein levels and eventually suppressed STAT3 signal pathway in NCI-H820 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

666.64

C₃₄H₃₃F₃N₄O₇

C[C@@]12CC/C=C(CN3C=C(N=N3)COC4=CC=C(C=C4)C(/C=C/C5=CC=CN=C5)=O)\CC[C@@H]6[C@H](OC(C6=C)=O)[C@H]1O2.OC(C(F)(F)F)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bai Y, et al. Design, synthesis and bioactivity evaluation of parthenolide-chalcone hybrids as potential anti-lung cancer agents. Bioorg Chem. 2025 Jul 26;164:108808.  [Content Brief]