2. Gene
  3. FGR - FGR proto-oncogene, Src family tyrosine kinase Gene

FGR - FGR proto-oncogene, Src family tyrosine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr

Gene ID: 2268 | Gene type: protein coding

About FGR

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,612,064-27,635,185 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues and 32 paralogues. Biased expression in bone marrow (RPKM 57.8), spleen (RPKM 29.9) and 6 other tissues.

Summary

This gene is a member of the Src family of Protein Tyrosine Kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 Integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

FGR Products(3)

mRNA Protein Name
NM_001042729.2 NP_001036194.1 tyrosine-protein kinase Fgr
NM_001042747.2 NP_001036212.1 tyrosine-protein kinase Fgr
NM_005248.3 NP_005239.1 tyrosine-protein kinase Fgr

FGR Protein Structure

SH3_1

SH3_1: SH3 domain (83 - 130)

SH2

SH2: SH2 domain (144 - 226)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (263 - 512)

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  • 529 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase Fgr

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

Related Diseases

Diseases Alias
Placental Insufficiency

Uteroplacental Vascular Insufficiency
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Cd45 Deficiency
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy
Pfeiffer Syndrome

Infectious Mononucleosis

Acs5

Craniofacial-Skeletal-Dermatologic Dysplasia

Acs V

Noack Syndrome

Gammaherpesviral Mononucleosis

Acrocephalosyndactyly Type 5

Pfeiffer Syndrome Type 3

Acrocephalosyndactyly, Type V

Glandular Fever

Pfeiffer Type Acrocephalosyndactyly

Pfeiffer Syndrome Type 2

Acrocephalosyndactylia Type V

Filatov'S Disease

Monocytic Angina

Mononucleosis

Pfeiffer'S Disease

Acsv

Acrocephalosyndactyly, Type 5

Craniofacial-Skeletal-Dermatologic Syndrome

Pfeiffer Syndrome Type 1

Classic Pfeiffer Syndrome

PS

Pfeiffer Syndrome Variant

Dysplasia, Craniofacial-Skeletal-Dermatologic

Pfeiffer

Kissing Disease

Infectious Adenitis

Pfeiffer Disease
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia
Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes

PPROM

Preterm Premature Rupture Of The Membranes, Susceptibility To

Pprom - [Preterm Premature Rupture Of Membranes]

Preterm Rupture Of Membranes
Oligohydramnios

Oligohydramnios - Delivered

Antepartum Oligohydramnios

Delivered Oligohydramnios

Oligohydramnios, Antepartum Condition Or Complication

Deficient Liquor

Oligohydramnios, Unspecified Trimester

Reduced Liquor Volume
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10230 Midostaurin 99.95% Yes
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-10234 Saracatinib 99.92% Phase 3
HY-10186 TG 100801 Inhibitor 98.60% Phase 2
HY-10187 TG 100801 Hydrochloride Inhibitor / Phase 2
HY-15322 PRT062607 Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15141 Staurosporine 99.98% Unkown
HY-112852 TL02-59 99.84% Unkown
HY-10185 TG 100572 Hydrochloride Inhibitor 98.96% Unkown
HY-10230S Midostaurin-d5 Inhibitor ≥98.0% Unkown
HY-10184 TG 100572 Inhibitor / Unkown
HY-10234A Saracatinib difumarate Inhibitor 99.24% Yes
HY-112852A TL02-59 dihydrochloride / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-RS04929 FGR Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FGR VGNC VGNC:40866
Bos taurus FGR VGNC VGNC:28994
Mus musculus FGR MGD MGI:95527
Rattus norvegicus FGR RGD RGD:621319
Macaca mulatta FGR VGNC VGNC:72658
Felis catus FGR VGNC VGNC:62262
Others FGR NCBI