TPM1 - tropomyosin 1 Gene
Also Known as CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha
Species: Homo sapiens
About TPM1
This gene has 39 transcripts (splice variants), 248 orthologues, 3 paralogues and is associated with 6 phenotypes. Biased expression in heart (RPKM 615.8), prostate (RPKM 140.5) and 9 other tissues.
Summary
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the Cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and Myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]
TPM1 Products (40)
| mRNA | Protein | Name |
|---|---|---|
| NM_000366.6 | NP_000357.3 | tropomyosin alpha-1 chain isoform Tpm1.5cy |
| NM_001018004.2 | NP_001018004.1 | tropomyosin alpha-1 chain isoform Tpm1.6cy |
| NM_001018005.2 | NP_001018005.1 | tropomyosin alpha-1 chain isoform Tpm1.1st |
| NM_001018006.2 | NP_001018006.1 | tropomyosin alpha-1 chain isoform Tpm1.7cy |
| NM_001018007.2 | NP_001018007.1 | tropomyosin alpha-1 chain isoform Tpm1.4sm |
| NM_001018008.2 | NP_001018008.1 | tropomyosin alpha-1 chain isoform Tpm1.12br |
| NM_001018020.2 | NP_001018020.1 | tropomyosin alpha-1 chain isoform Tpm1.3sm |
| NM_001301244.2 | NP_001288173.1 | tropomyosin alpha-1 chain isoform Tpm1.2st |
| NM_001301289.2 | NP_001288218.1 | tropomyosin alpha-1 chain isoform Tpm1.8cy |
| NM_001330344.2 | NP_001317273.1 | tropomyosin alpha-1 chain isoform Tpm1.9cy |
| NM_001330346.2 | NP_001317275.1 | tropomyosin alpha-1 chain isoform Tpm1.13 |
| NM_001330351.2 | NP_001317280.1 | tropomyosin alpha-1 chain isoform 12 |
| NM_001365776.1 | NP_001352705.1 | tropomyosin alpha-1 chain isoform Tpm1.10br |
| NM_001365777.1 | NP_001352706.1 | tropomyosin alpha-1 chain isoform 14 |
| NM_001365778.1 | NP_001352707.1 | tropomyosin alpha-1 chain isoform 15 |
| NM_001365779.1 | NP_001352708.1 | tropomyosin alpha-1 chain isoform 16 |
| NM_001365780.1 | NP_001352709.1 | tropomyosin alpha-1 chain isoform Tpm1.11br |
| NM_001365781.2 | NP_001352710.1 | tropomyosin alpha-1 chain isoform 18 |
| NM_001365782.1 | NP_001352711.1 | tropomyosin alpha-1 chain isoform 19 |
| NM_001407322.1 | NP_001394251.1 | tropomyosin alpha-1 chain isoform 23 |
| NM_001407323.1 | NP_001394252.1 | tropomyosin alpha-1 chain isoform 24 |
| NM_001407324.1 | NP_001394253.1 | tropomyosin alpha-1 chain isoform 25 |
| NM_001407325.1 | NP_001394254.1 | tropomyosin alpha-1 chain isoform 26 |
| NM_001407326.1 | NP_001394255.1 | tropomyosin alpha-1 chain isoform 27 |
| NM_001407327.1 | NP_001394256.1 | tropomyosin alpha-1 chain isoform 28 |
| NM_001407328.1 | NP_001394257.1 | tropomyosin alpha-1 chain isoform 29 |
| NM_001407329.1 | NP_001394258.1 | tropomyosin alpha-1 chain isoform 30 |
| NM_001407330.1 | NP_001394259.1 | tropomyosin alpha-1 chain isoform Tpm1.5cy |
| NM_001407331.1 | NP_001394260.1 | tropomyosin alpha-1 chain isoform 31 |
| NM_001407332.1 | NP_001394261.1 | tropomyosin alpha-1 chain isoform 32 |
| NM_001407333.1 | NP_001394262.1 | tropomyosin alpha-1 chain isoform 16 |
| NM_001407334.1 | NP_001394263.1 | tropomyosin alpha-1 chain isoform 33 |
| NM_001407335.1 | NP_001394264.1 | tropomyosin alpha-1 chain isoform 33 |
| NM_001407336.1 | NP_001394265.1 | tropomyosin alpha-1 chain isoform 35 |
| NM_001407337.1 | NP_001394266.1 | tropomyosin alpha-1 chain isoform 36 |
| NM_001407338.1 | NP_001394267.1 | tropomyosin alpha-1 chain isoform 37 |
| NM_001407340.1 | NP_001394269.1 | tropomyosin alpha-1 chain isoform 38 |
| NM_001407341.1 | NP_001394270.1 | tropomyosin alpha-1 chain isoform 39 |
| NM_001407342.1 | NP_001394271.1 | tropomyosin alpha-1 chain isoform 40 |
| NM_001407344.1 | NP_001394273.1 | tropomyosin alpha-1 chain isoform 41 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cytoskeletal protein binding |
IPI
IPI: Inferred from physical interaction
|
17987659 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cardiac muscle contraction |
IMP
IMP: Inferred from mutant phenotype
|
11136687 | GOA |
| involved in cellular response to reactive oxygen species |
IEP
IEP: Inferred from expression pattern
|
12686598 | GOA |
| involved in negative regulation of vascular associated smooth muscle cell migration |
IMP
IMP: Inferred from mutant phenotype
|
21817107 | GOA |
| involved in negative regulation of vascular associated smooth muscle cell proliferation |
IMP
IMP: Inferred from mutant phenotype
|
21817107 | GOA |
| involved in regulation of cell shape |
IMP
IMP: Inferred from mutant phenotype
|
21817107 | GOA |
| involved in sarcomere organization |
IMP
IMP: Inferred from mutant phenotype
|
11273725 | GOA |
| involved in ventricular cardiac muscle tissue morphogenesis |
IMP
IMP: Inferred from mutant phenotype
|
11136687 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in bleb |
IMP
IMP: Inferred from mutant phenotype
|
12686598 | GOA |
| located in ruffle membrane |
IDA
IDA: Inferred from direct assay
|
12686598 | GOA |
| located in stress fiber |
IDA
IDA: Inferred from direct assay
|
12686598 | GOA |
TPM1 Protein Structure
Tropomyosin: Tropomyosin (48 - 283)
- 0
- 100
- 200
- 284 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
tropomyosin alpha-1 chain |
|
TPM1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TPM1 | P09493 | CAGE1 | Homo sapiens | Q8TC20 | 25416956 | |
|
Intra
|
TPM1 | P09493 | CAGE1 | Homo sapiens | Q8TC20 | 25416956 | |
|
Intra
|
TPM1 | P09493 | TPM2 | Homo sapiens | P07951 | 33961781 | |
|
Intra
|
TPM1 | P09493 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
TPM1 | P09493 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
TPM1 | P09493 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
TPM1 | P09493 | SYCE1 | Homo sapiens | Q8N0S2 | 25416956 | |
|
Intra
|
TPM1 | P09493 | SYCE1 | Homo sapiens | Q8N0S2 | 25416956 | |
|
Intra
|
TPM1 | P09493 | TNNT1 | Homo sapiens | P13805 | 25416956 | |
|
Intra
|
TPM1 | P09493 | TNNT1 | Homo sapiens | P13805 | 25416956 | |
|
Intra
|
TPM1 | P09493 | KXD1 | Homo sapiens | Q9BQD3 | 16189514 | |
|
Intra
|
TPM1 | P09493 | KXD1 | Homo sapiens | Q9BQD3 | 33961781 | |
|
Intra
|
TPM1 | P09493 | KXD1 | Homo sapiens | Q9BQD3 | 25416956 | |
|
Intra
|
TPM1 | P09493 | KXD1 | Homo sapiens | Q9BQD3 | 25416956 | |
|
Intra
|
TPM1 | P09493 | MAD1L1 | Homo sapiens | Q9Y6D9 | 33961781 | |
|
Intra
|
TPM1 | P09493 | MAD1L1 | Homo sapiens | Q9Y6D9 | 25416956 | |
|
Intra
|
TPM1 | P09493 | MAD1L1 | Homo sapiens | Q9Y6D9 | 26871637 | |
|
Intra
|
TPM1 | P09493 | MAD1L1 | Homo sapiens | Q9Y6D9 | 25416956 | |
|
Intra
|
TPM1 | P09493 | MAD1L1 | Homo sapiens | Q9Y6D9 | 26871637 | |
|
Intra
|
TPM1 | P09493 | MAD1L1 | Homo sapiens | Q9Y6D9 | 25416956 | |
|
Intra
|
TPM1 | P09493 | MAD1L1 | Homo sapiens | Q9Y6D9 | 26871637 | |
|
Intra
|
TPM1 | P09493 | C1orf216 | Homo sapiens | Q8TAB5 | 25416956 |
Recombinant TPM1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P74502 | TPM1 Protein, Human (His) | P09493-10/NP_000357.3 (M1-M284) | ≥ 90%, as determined by reducing SDS-PAGE. |
TPM1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82438 | Tropomyosin alpha 1 Chain Antibody (YA2183) | WB, IHC-P, ICC/IF, IP, FC | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cardiomyopathy, Familial Hypertrophic, 3 |
|
|
| Cardiomyopathy, Dilated, 1e |
|
|
| Cardiomyopathy, Familial Hypertrophic, 1 |
|
|
| Dilated Cardiomyopathy |
|
|
| Hypertrophic Cardiomyopathy |
|
|
| Left Ventricular Noncompaction |
|
|
| Familial Isolated Dilated Cardiomyopathy |
|
|
| Pulmonary Atresia With Intact Ventricular Septum |
|
|
| Atrial Septal Defect 1 |
|
|
| Ebstein Anomaly |
|
|
| Tetralogy Of Fallot |
|
|
| Arteriosclerosis Obliterans |
|
|
| Arthrogryposis, Distal, Type 1a |
|
|
| Cardiomyopathy, Dilated, 1ee |
|
|
| Arthrogryposis, Distal, Type 5 |
|
|
| Clubfoot |
|
|
| Cardiomyopathy, Familial Hypertrophic, 25 |
|
|
| Brugada Syndrome |
|
|
| Cardiomyopathy, Familial Hypertrophic, 4 |
|
|
| Intrinsic Cardiomyopathy |
|
|
| Breast Cancer |
|
|
| Restrictive Cardiomyopathy |
|
|
| Myopathy |
|
|
| Arrhythmogenic Right Ventricular Cardiomyopathy |
|
|
| Rasopathy |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | TPM1 | RGD | RGD:3898 |
| Canis familiaris | TPM1 | VGNC | VGNC:55006 |
| Mus musculus | TPM1 | MGD | MGI:98809 |
| Felis catus | TPM1 | VGNC | VGNC:80814 |
| Bos taurus | TPM1 | VGNC | VGNC:106994 |
| Macaca mulatta | TPM1 | VGNC | VGNC:78634 |
| Others | TPM1 | NCBI |