TPM1 - tropomyosin 1 Gene

Homo sapiens

Also known as CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha

Gene ID: 7168 | Gene type: protein coding

About TPM1

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:63,042,747-63,071,915 (from NCBI)

This gene has 39 transcripts (splice variants), 248 orthologues, 3 paralogues and is associated with 6 phenotypes. Biased expression in heart (RPKM 615.8), prostate (RPKM 140.5) and 9 other tissues.

Summary

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the Cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and Myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]

TPM1 Products(40)

mRNA	Protein	Name
NM_000366.6	NP_000357.3	tropomyosin alpha-1 chain isoform Tpm1.5cy
NM_001018004.2	NP_001018004.1	tropomyosin alpha-1 chain isoform Tpm1.6cy
NM_001018005.2	NP_001018005.1	tropomyosin alpha-1 chain isoform Tpm1.1st
NM_001018006.2	NP_001018006.1	tropomyosin alpha-1 chain isoform Tpm1.7cy
NM_001018007.2	NP_001018007.1	tropomyosin alpha-1 chain isoform Tpm1.4sm
NM_001018008.2	NP_001018008.1	tropomyosin alpha-1 chain isoform Tpm1.12br
NM_001018020.2	NP_001018020.1	tropomyosin alpha-1 chain isoform Tpm1.3sm
NM_001301244.2	NP_001288173.1	tropomyosin alpha-1 chain isoform Tpm1.2st
NM_001301289.2	NP_001288218.1	tropomyosin alpha-1 chain isoform Tpm1.8cy
NM_001330344.2	NP_001317273.1	tropomyosin alpha-1 chain isoform Tpm1.9cy
NM_001330346.2	NP_001317275.1	tropomyosin alpha-1 chain isoform Tpm1.13
NM_001330351.2	NP_001317280.1	tropomyosin alpha-1 chain isoform 12
NM_001365776.1	NP_001352705.1	tropomyosin alpha-1 chain isoform Tpm1.10br
NM_001365777.1	NP_001352706.1	tropomyosin alpha-1 chain isoform 14
NM_001365778.1	NP_001352707.1	tropomyosin alpha-1 chain isoform 15
NM_001365779.1	NP_001352708.1	tropomyosin alpha-1 chain isoform 16
NM_001365780.1	NP_001352709.1	tropomyosin alpha-1 chain isoform Tpm1.11br
NM_001365781.2	NP_001352710.1	tropomyosin alpha-1 chain isoform 18
NM_001365782.1	NP_001352711.1	tropomyosin alpha-1 chain isoform 19
NM_001407322.1	NP_001394251.1	tropomyosin alpha-1 chain isoform 23
NM_001407323.1	NP_001394252.1	tropomyosin alpha-1 chain isoform 24
NM_001407324.1	NP_001394253.1	tropomyosin alpha-1 chain isoform 25
NM_001407325.1	NP_001394254.1	tropomyosin alpha-1 chain isoform 26
NM_001407326.1	NP_001394255.1	tropomyosin alpha-1 chain isoform 27
NM_001407327.1	NP_001394256.1	tropomyosin alpha-1 chain isoform 28
NM_001407328.1	NP_001394257.1	tropomyosin alpha-1 chain isoform 29
NM_001407329.1	NP_001394258.1	tropomyosin alpha-1 chain isoform 30
NM_001407330.1	NP_001394259.1	tropomyosin alpha-1 chain isoform Tpm1.5cy
NM_001407331.1	NP_001394260.1	tropomyosin alpha-1 chain isoform 31
NM_001407332.1	NP_001394261.1	tropomyosin alpha-1 chain isoform 32
NM_001407333.1	NP_001394262.1	tropomyosin alpha-1 chain isoform 16
NM_001407334.1	NP_001394263.1	tropomyosin alpha-1 chain isoform 33
NM_001407335.1	NP_001394264.1	tropomyosin alpha-1 chain isoform 33
NM_001407336.1	NP_001394265.1	tropomyosin alpha-1 chain isoform 35
NM_001407337.1	NP_001394266.1	tropomyosin alpha-1 chain isoform 36
NM_001407338.1	NP_001394267.1	tropomyosin alpha-1 chain isoform 37
NM_001407340.1	NP_001394269.1	tropomyosin alpha-1 chain isoform 38
NM_001407341.1	NP_001394270.1	tropomyosin alpha-1 chain isoform 39
NM_001407342.1	NP_001394271.1	tropomyosin alpha-1 chain isoform 40
NM_001407344.1	NP_001394273.1	tropomyosin alpha-1 chain isoform 41

TPM1 Protein Structure

Tropomyosin

0
100
200
284 a.a.

Protein Preferred Names

Protein Names

tropomyosin alpha-1 chain

cardiomyopathy, hypertrophic 3

Recombinant TPM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74502	TPM1 Protein, Human (His)	P09493-10/NP_000357.3 (M1-M284)	≥95%

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 3

Hypertrophic Cardiomyopathy 3	CMH3
Cardiomyopathy, Hypertrophic, 3	Cardiomyopathy Familial Hypertrophic 3
Cardiomyopathy, Familial Hypertrophic 3	Cardiomyopathy, Hypertrophic, Familial, Type 3

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Pulmonary Atresia With Intact Ventricular Septum

Pulmonary Atresia-Intact Ventricular Septum Syndrome

Pulmonary Valve Atresia With Intact Ventricular Septum

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Ebstein Anomaly

Ebstein'S Anomaly	Ebstein'S Anomaly Of Common Atrioventricular Valve
Ebstein'S Anomaly Of Right Atrioventricular Valve	Ebstein'S Anomaly Of Tricuspid Valve
Ebstein'S Malformation	Ebstein Malformation Of The Tricuspid Valve
Ebstein Anomaly Of The Tricuspid Valve	Ebstein Disease
Accessory Tricuspid Valve Tissue	Congenital Ebstein Deformity Of Tricuspid Valve
Ebstein Syndrome	Ebstein Cardiopathy
Ebstein Anomaly Of Tricuspid Valve

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Arteriosclerosis Obliterans

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Cardiomyopathy, Dilated, 1ee

Dilated Cardiomyopathy 1ee	CMD1EE
Cardiomyopathy, Dilated 1ee	Cardiomyopathy, Dilated, Type 1ee

Arthrogryposis, Distal, Type 5

Oculomelic Amyoplasia	Distal Arthrogryposis Type 5
Distal Arthrogryposis Type Iib	DA5
Arthrogryposis With Oculomotor Limitation And Electroretinal Abnormalities	Daiib
Distal Arthrogryposis Type 2b	Arthrogryposis-Oculomotor Limitation-Electroretinal Anomalies Syndrome
Distal Arthrogryposis With Ophthalmoplegia	Arthrogryposis- Oculomotor Limitation-Electroretinal Anomalies Syndrome
Arthrogryposis, Distal, Type Iib	Da2b
Freeman-Sheldon Syndrome Variant	Sheldon-Hall Syndrome
Arthogryposis With Oculomotor Limitation And Electroretinal Abnormalities	Arthrogryposis Ophthalmoplegia Retinopathy
Arthrogryposis, Distal, 5	Arthrogryposis, Distal, Type 2b

Clubfoot

Congenital Talipes Equinovarus	Congenital Clubfoot
Congenital Equinovarus	Equinovarus Deformity Of Foot
Club Foot

Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25	CMH25
Cardiomyopathy, Hypertrophic, 25	Cardiomyopathy Familial Hypertrophic 25
Cardiomyopathy, Familial Hypertrophic 25	Cardiomyopathy, Hypertrophic, Type 25

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Cardiomyopathy, Familial Hypertrophic, 4

Hypertrophic Cardiomyopathy 4	CMH4
Cardiomyopathy, Hypertrophic, 4	Cardiomyopathy, Familial Hypertrophic 4
Cardiomyopathy, Familial Hypertrophic, 4, Susceptibility To	Cardiomyopathy, Hypertrophic, Familial, Type 4

Intrinsic Cardiomyopathy

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy	Cardiomyopathy, Restrictive
Cardiomyopathy, Constrictive	Primary Restrictive Cardiomyopathy
Rcm	Cardiomyopathy Restrictive

Myopathy

Muscular Diseases

Myopathies

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14936	TPM1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TPM1	RGD	RGD:3898
Canis familiaris	TPM1	VGNC	VGNC:55006
Mus musculus	TPM1	MGD	MGI:98809
Felis catus	TPM1	VGNC	VGNC:80814
Bos taurus	TPM1	VGNC	VGNC:106994
Macaca mulatta	TPM1	VGNC	VGNC:78634
Others	TPM1	NCBI