TPM1 Protein, Human (His)

TPM1 Protein, a member of the tropomyosin family, belongs to a highly conserved group of actin-binding proteins crucial for the contractile system in striated and smooth muscles, as well as the cytoskeleton of non-muscle cells. Comprising two alpha-helical chains arranged as a coiled-coil, tropomyosin polymerizes along the grooves of actin filaments, providing structural stability. This protein, a key alpha helical chain, serves as the predominant tropomyosin in striated muscle, where it collaborates with the troponin complex to regulate the calcium-dependent interaction between actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternative splicing yields various isoforms. Mutations in the TPM1 gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. Moreover, TPM1 displays biased expression, with notable levels observed in the heart and prostate, along with nine other tissues, underscoring its importance in diverse physiological contexts.