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Cat. No.: HY-148373

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BRM/BRG1 ATP Inhibitor-3

BRM/BRG1 ATP Inhibitor-3 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-3 inhibits BRM and BRG1 with IC₅₀ values of 10.4 nM and 19.3 nM, respectively. BRM/BRG1 ATP Inhibitor-3 can be used for the research of cancers and BAF complex-related disorders.

For research use only. We do not sell to patients.

CAS No.: 2368901-31-7
Formula: C₂₆H₂₅N₅O₂S₂
Molecular Weight:503.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

BRM/BRG1 ATP Inhibitor-3 Chemical Structure

CAS No.: 2368901-31-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC50: 10.4 nM (BRM); 19.3 nM (BRG1)^[1].

All SWI/SNF Complex Isoforms :

In Vitro

BRM/BRG1 ATP Inhibitor-3 has inhibitory activity for BRM and BRG1 with IC₅₀ values of 10.4 nM and 19.3 nM, respectively^[1].
BRM/BRG1 ATP Inhibitor-3 (0.01-10 μM) has inhibition for cell proliferation in several cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Proliferation Assay^[1]

View Protocol

Cell Line:

Uveal melanoma cell lines (92-1 , MP41 , MP38, MP46), prostate cancer cell lines (LNCAP), lung cancer cell lines (NCI-H1299), and immortalized embryonic kidney lines (HEK293T)
Concentration:

0-10 μM
Incubation Time:

3 days
Result:

Inhibited cell proliferation of uveal melanoma cell line 92-1 and MP41.

Chemical Information

CAS No. 2368901-31-7
Molecular Weight 503.64
Formula C₂₆H₂₅N₅O₂S₂
SMILES

O=C(C1=CC=C(C=C1)N)N[C@@H](CCSC)C(NC2=NC(C3=CC(C4=CC=NC=C4)=CC=C3)=CS2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kevin J. Wilson, et al. Compounds and uses thereof. Patent. WO2021155320A1.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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