CYTIP - cytohesin 1 interacting protein Gene

Also Known as HE; B3-1; CASP; CYBR; CYTHIP; PSCDBP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9595

About CYTIP

Cytogenetic location: 2q24.1 Genomic coordinates (GRCh38): 2:157,414,619-157,444,089 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 28.7), bone marrow (RPKM 27.5) and 11 other tissues.

Summary

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]

CYTIP Products (1)

mRNA Protein Name
NM_004288.5 NP_004279.3 cytohesin-interacting protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11867758 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within regulation of cell adhesion IDA
IDA: Inferred from direct assay
12606567 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cell cortex IDA
IDA: Inferred from direct assay
12606567 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12606567 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYTIP Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (78 - 161)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

cytohesin-interacting protein

  • cbp HE

CYTIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CYTIP O60759 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
CYTIP O60759 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
CYTIP O60759 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
CYTIP O60759 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
CYTIP O60759 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
CYTIP O60759 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
CYTIP O60759 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
CYTIP O60759 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
CYTIP O60759 KIF9 Homo sapiens Q9HAQ2
Validated Y2H
32296183
Intra
CYTIP O60759 CYTH1 Homo sapiens Q15438
Anti Tag CoIP
11867758
Intra
CYTIP O60759 CYTH1 Homo sapiens Q15438
Y2H Prey Pooling
32296183
Intra
CYTIP O60759 CYTH1 Homo sapiens Q15438
Anti Tag CoIP
28514442
Intra
CYTIP O60759 CYTH1 Homo sapiens Q15438
Validated Y2H
32296183
Intra
CYTIP O60759 CYTH1 Homo sapiens Q15438
Anti Tag CoIP
33961781
Intra
CYTIP O60759 CYTH1 Homo sapiens Q15438
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03503 CYTIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20007 Cytip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26510 Cytip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CYTIP MGD MGI:2183535
Macaca mulatta CYTIP VGNC VGNC:71831
Canis familiaris CYTIP VGNC VGNC:50297
Bos taurus CYTIP VGNC VGNC:49051
Rattus norvegicus CYTIP RGD RGD:1307990
Felis catus CYTIP VGNC VGNC:69098
Others CYTIP NCBI