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WBP11 - WW domain binding protein 11 Gene

Also Known as BUG13; FAP90; NPWBP; SIPP1; VCTRL; CFAP90; VCTERL; WBP-11; PPP1R165

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51729

About WBP11

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:14,784,582-14,803,478 (from NCBI)

This gene has 5 transcripts (splice variants), 17 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 48.6), bone marrow (RPKM 38.2) and 25 other tissues.

Summary

This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]

WBP11 Products (1)

mRNA	Protein	Name
NM_016312.3	NP_057396.1	WW domain-binding protein 11

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	19592703	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16000308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WBP11 Protein Structure

Wbp11

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641 a.a.

Protein Preferred Names	Protein Names
WW domain-binding protein 11	Npw38-binding protein NpwBP

WBP11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WBP11	Q9Y2W2	MCRS1	Homo sapiens	Q96EZ8	MAPPIT	32296183
Intra	WBP11	Q9Y2W2	PPP1CA	Homo sapiens	P62136	Y2H	22321011
Intra	WBP11	Q9Y2W2	PPP1CA	Homo sapiens	P62136	Y2H	22365833
Intra	WBP11	Q9Y2W2	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	25416956
Intra	WBP11	Q9Y2W2	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	25416956
Intra	WBP11	Q9Y2W2	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	25416956
Intra	WBP11	Q9Y2W2	GRB2	Homo sapiens	P62993	Validated Y2H	25416956
Intra	WBP11	Q9Y2W2	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	WBP11	Q9Y2W2	FYN	Homo sapiens	P06241	Validated Y2H	25416956
Intra	WBP11	Q9Y2W2	FYN	Homo sapiens	P06241	Y2H Array	25416956
Intra	WBP11	Q9Y2W2	PQBP1	Homo sapiens	O60828	MAPPIT	25416956
Intra	WBP11	Q9Y2W2	PQBP1	Homo sapiens	O60828	Anti Tag CoIP	25416956
Intra	WBP11	Q9Y2W2	PQBP1	Homo sapiens	O60828	Anti Tag CoIP	33961781
Intra	WBP11	Q9Y2W2	TESC	Homo sapiens	Q96BS2	Y2H Array	25416956
Intra	WBP11	Q9Y2W2	C5orf22	Homo sapiens	Q49AR2	Anti Tag CoIP	33961781
Intra	WBP11	Q9Y2W2	C5orf22	Homo sapiens	Q49AR2	Anti Tag CoIP	28514442
Intra	WBP11	Q9Y2W2	C5orf22	Homo sapiens	Q49AR2	Y2H Pooling	16189514
Intra	WBP11	Q9Y2W2	CD2BP2	Homo sapiens	O95400	Y2H	16000308
Intra	WBP11	Q9Y2W2	CD2BP2	Homo sapiens	O95400	Protein Array	16000308
Cross	WBP11	Q9Y2W2	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Y2H	24136289

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects	VCTERL Vcterl Syndrome VCTRL
Baastrup'S Syndrome	Kissing Spine Baastrup Syndrome Kissing Spine, Site Unspecified Osteoarthrosis Interspinalis Overriding Of Dorsal Spinous Processes Localised Idiopathic Skeletal Hyperostosis Baastrup Disease
Renpenning Syndrome 1	Renpenning Syndrome Golabi-Ito-Hall Syndrome Mrxs3 Mrxs8 X-Linked Intellectual Disability Due To Pqbp1 Mutations RENS1 Sutherland-Haan X-Linked Mental Retardation Syndrome Shs Mrx55 X-Linked Intellectual Disability, Renpenning Type Sutherland-Haan Syndrome Mental Retardation, X-Linked, Renpenning Type Mental Retardation, X-Linked, With Spastic Diplegia Mental Retardation, X-Linked, Syndromic 3 Mental Retardation, X-Linked, Syndromic 8 Mental Retardation, X-Linked 55 Syndromic X-Linked Mental Retardation 8 X-Linked Mental Retardation Renpenning Type X-Linked Mental Retardation With Spastic Diplegia Sutherland-Haan X-Linked Intellectual Disability Syndrome X-Linked Intellectual Disability With Spastic Diplegia Hamel Cerebropalatocardiac Syndrome Porteous Syndrome X-Linked Intellectual Deficit Due To Pqbp1 Mutations X-Linked Intellectual Deficit, Renpenning Type X-Linked Intellectual Disability, Sutherland-Haan Type Hamel Cerebro-Palato-Cardiac Syndrome Renpenning Syndrome, Type 1
Olmsted Syndrome, X-Linked	OLMSX Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked Ppkmx X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques X-Linked Olmsted Syndrome Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2	Abdominal Obesity-Metabolic Syndrome Abdominal Obesity Metabolic Syndrome Metabolic Syndrome X Aoms2 Aoms1
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Fanconi Anemia, Complementation Group D2	Fanconi Anemia Complementation Group D2 FANCD2 Fad2 Fa4 Fancd Fanconi Pancytopenia Type 4 Fanconi Anemia, Complementation Group D Fanconi Pancytopenia, Type 4 Facd Fanconi Anemia Complementation Group D
Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15749	WBP11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WBP11	VGNC	VGNC:99700
Canis familiaris	WBP11	VGNC	VGNC:48339
Rattus norvegicus	WBP11	RGD	RGD:1307911
Mus musculus	WBP11	MGD	MGI:1891823
Others	WBP11	NCBI