AGGF1 - angiogenic factor with G-patch and FHA domains 1 Gene

Also Known as VG5Q; GPATC7; GPATCH7; HSU84971; HUS84971

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55109

About AGGF1

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:77,030,404-77,065,234 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 13.2), brain (RPKM 10.3) and 25 other tissues.

Summary

This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]

AGGF1 Products (1)

mRNA	Protein	Name
NM_018046.5	NP_060516.2	angiogenic factor with G patch and FHA domains 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14961121	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	14961121	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	14961121	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	14961121	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14961121	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	14961121	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14961121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGGF1 Protein Structure

FHA

G-patch

0
200
400
600
714 a.a.

Protein Preferred Names	Protein Names
angiogenic factor with G patch and FHA domains 1	G patch domain-containing protein 7

AGGF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGGF1	Q8N302	MAB21L3	Homo sapiens	Q8N8X9	Y2H Array	31515488
Intra	AGGF1	Q8N302	MAB21L3	Homo sapiens	Q8N8X9	Validated Y2H	32296183
Intra	AGGF1	Q8N302	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	AGGF1	Q8N302	FBXO28	Homo sapiens	Q9NVF7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Metatypical Basal Cell Carcinoma	Skin Metatypical Carcinoma Basosquamous Carcinoma Of Skin Skin Metatypical Basal Cell Carcinoma
Frontal Convexity Meningioma
Varicose Veins	Varices Varix Venous Ectasia Venous Varices Varicosity
Angiokeratoma Circumscriptum
Venous Malformations, Multiple Cutaneous And Mucosal	VMCM Multiple Cutaneous And Mucosal Venous Malformations Mucocutaneous Venous Malformations Vmcm1 Cutaneous And Mucosal Venous Malformation Dominantly Inherited Venous Malformations
Hemangioma Of Subcutaneous Tissue	Angioma Of The Subcutaneous Tissue Subcutaneous Haemangioma Subcutaneous Hemangioma
Thrombocytopenia With Beta-Thalassemia, X-Linked	XLTT Thrombocytopenia, Platelet Dysfunction, Hemolysis, And Imbalanced Globin Synthesis Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome Gata1-Related X-Linked Cytopenia X-Linked Thrombocytopenia With Beta-Thalassemia Thrombocytopenia Platelet Dysfunction Hemolysis And Imbalanced Globin Synthesis
Capillary Lymphangioma	Microcystic Lymphatic Malformation Capillary Lymphatic Malformation Microcystic Infiltrating Lymphatic Malformation Microcystic Lymphangioma Superficial Lymphangioma Cutaneous Lymphangioma Circumscriptum Superficial Lymphatic Malformation Cutaneous Lymphangioma Lymphangioma Of Skin Lymphangioma Circumscriptum
Multiple Enchondromatosis, Maffucci Type	Maffucci Syndrome Chondrodysplasia With Hemangioma Chondroplasia Angiomatosis Enchondromatosis With Hemangiomata Hemangiomatosis Chondrodystrophica Kast Syndrome Multiple Angiomas And Endochondromas Dyschondrodysplasia With Hemangiomas Enchondromatosis Type Ii Enchondromatosis With Multiple Cavernous Hemangiomas Dyschondroplasia And Cavernous Hemangioma Hemangiomata With Dyschondroplasia
Angiomatous Meningioma
Proteus Syndrome	Proteus Syndrome, Somatic Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly Wiedemann'S Syndrome Hemihypertrophy And Macrocephaly Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly Ps PROTEUSS Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00447	AGGF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AGGF1	RGD	RGD:1310888
Canis familiaris	AGGF1	VGNC	VGNC:37702
Mus musculus	AGGF1	MGD	MGI:1913799
Bos taurus	AGGF1	VGNC	VGNC:25727
Others	AGGF1	NCBI