KAT7 - lysine acetyltransferase 7 Gene

Also Known as HBO1; HBOA; MYST2; ZC2HC7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11143

About KAT7

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,788,681-49,835,026 (from NCBI)

This gene has 19 transcripts (splice variants), 267 orthologues, 9 paralogues and is associated with 64 phenotypes. Broad expression in testis (RPKM 37.1), bone marrow (RPKM 22.8) and 24 other tissues.

Summary

The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]

KAT7 Products (6)

mRNA Protein Name
NM_001199155.2 NP_001186084.1 histone acetyltransferase KAT7 isoform 2
NM_001199156.2 NP_001186085.1 histone acetyltransferase KAT7 isoform 3
NM_001199157.2 NP_001186086.1 histone acetyltransferase KAT7 isoform 4
NM_001199158.2 NP_001186087.1 histone acetyltransferase KAT7 isoform 5
NM_001346706.2 NP_001333635.1 histone acetyltransferase KAT7 isoform 6
NM_007067.5 NP_008998.1 histone acetyltransferase KAT7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA replication origin binding IMP
IMP: Inferred from mutant phenotype
21856198 GOA
enables histone H3K14 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
enables histone H3K23 acetyltransferase activity IDA
IDA: Inferred from direct assay
24065767 GOA
enables histone H3K4 acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
21856198 GOA
enables histone H4 acetyltransferase activity IDA
IDA: Inferred from direct assay
24065767 GOA
enables histone H4K12 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
NOT enables histone H4K16 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
enables histone H4K5 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
enables histone H4K8 acetyltransferase activity IDA
IDA: Inferred from direct assay
16387653 GOA
enables histone acetyltransferase activity IDA
IDA: Inferred from direct assay
28719581 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10930412 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA replication-dependent chromatin disassembly IDA
IDA: Inferred from direct assay
16387653 GOA
involved in internal peptidyl-lysine acetylation IDA
IDA: Inferred from direct assay
26221039 GOA
involved in positive regulation of DNA replication IDA
IDA: Inferred from direct assay
26620551 GOA
involved in positive regulation of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
31827282 GOA
involved in positive regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
24739512 GOA
involved in regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
16387653 GOA
involved in regulation of DNA replication IDA
IDA: Inferred from direct assay
16387653 GOA
involved in regulation of DNA-templated DNA replication initiation IDA
IDA: Inferred from direct assay
26620551 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22144582 GOA
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
16387653 GOA
involved in regulation of cell growth IDA
IDA: Inferred from direct assay
22144582 GOA
involved in regulation of nucleotide-excision repair IDA
IDA: Inferred from direct assay
28719581 GOA
involved in response to actinomycin D IMP
IMP: Inferred from mutant phenotype
21856198 GOA
involved in response to anisomycin IMP
IMP: Inferred from mutant phenotype
21856198 GOA
involved in response to dithiothreitol IMP
IMP: Inferred from mutant phenotype
21856198 GOA
involved in response to hydroxyurea IMP
IMP: Inferred from mutant phenotype
21856198 GOA
involved in response to sorbitol IMP
IMP: Inferred from mutant phenotype
21856198 GOA
involved in stress-activated protein kinase signaling cascade IDA
IDA: Inferred from direct assay
21856198 GOA
involved in transcription initiation-coupled chromatin remodeling IMP
IMP: Inferred from mutant phenotype
21856198 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
24065767 GOA
part of histone H3-K14 acetyltransferase complex IDA
IDA: Inferred from direct assay
21753189 GOA
part of histone acetyltransferase complex IDA
IDA: Inferred from direct assay
16387653 GOA
part of histone acetyltransferase complex IPI
IPI: Inferred from physical interaction
16387653 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
16387653 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
16387653 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21753189 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
28719581 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KAT7 Protein Structure

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (183 - 212)

MOZ_SAS

MOZ_SAS: MOZ/SAS family (390 - 574)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 611 a.a.
Protein Preferred Names Protein Names

histone acetyltransferase KAT7

  • K(lysine) acetyltransferase 7

KAT7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KAT7 O95251 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
KAT7 O95251 VIM Homo sapiens P08670
Y2H
21900206
Intra
KAT7 O95251 CEP126 Homo sapiens Q9P2H0
Y2H
15383276
Intra
KAT7 O95251 AR Homo sapiens P10275
Anti Tag CoIP
10930412
Intra
KAT7 O95251 AR Homo sapiens P10275
Y2H
10930412
Intra
KAT7 O95251 JADE1 Homo sapiens Q6IE81
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

KAT7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83282 KAT7/ Hbo1/MYST2 Antibody (YA3027) WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P83282A KAT7/ Hbo1/MYST2 Antibody (YA3027)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P83872 KAT7/ Hbo1/MYST2 Antibody (YA3569) WB, IHC-P, ELISA Human, Mouse, Monkey
HY-P83872A KAT7/ Hbo1/MYST2 Antibody (YA3569)(PBS only) WB, IHC-P, ELISA Human, Mouse, Monkey
HY-P85857 KAT7/ Hbo1/MYST2 Antibody (YA5549) WB, ICC/IF, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134901 WM-3835 99.78% Unkown
HY-102058 WM-1119 Inhibitor 99.57% Unkown
HY-176244 KI-TOX-A3 Inhibitor 99.15% Unkown
HY-168428 CHI-KAT8i5 98.00% Unkown
HY-177046 KAT6A/KAT7-IN-4 Inhibitor 98.86% Unkown
HY-177045 KAT6A/KAT7-IN-3 Inhibitor / Unkown
HY-RS07083 KAT7 Human Pre-designed siRNA Set A / Unkown
HY-RS16911 Kat7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177043 KAT6A/KAT7-IN-1 Inhibitor / Unkown
HY-177044 KAT6A/KAT7-IN-2 Inhibitor / Unkown
HY-RS23353 Kat7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KAT7 MGD MGI:2182799
Felis catus KAT7 VGNC VGNC:63026
Macaca mulatta KAT7 VGNC VGNC:99160
Bos taurus KAT7 VGNC VGNC:30403
Canis familiaris KAT7 VGNC VGNC:42214
Rattus norvegicus KAT7 RGD RGD:727966
Others KAT7 NCBI