2. Gene
  3. KAT7 - lysine acetyltransferase 7 Gene

KAT7 - lysine acetyltransferase 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HBO1; HBOA; MYST2; ZC2HC7

Gene ID: 11143 | Gene type: protein coding

About KAT7

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,788,681-49,835,026 (from NCBI)

This gene has 19 transcripts (splice variants), 267 orthologues, 9 paralogues and is associated with 64 phenotypes. Broad expression in testis (RPKM 37.1), bone marrow (RPKM 22.8) and 24 other tissues.

Summary

The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]

KAT7 Products(6)

mRNA Protein Name
NM_001199155.2 NP_001186084.1 histone acetyltransferase KAT7 isoform 2
NM_001199156.2 NP_001186085.1 histone acetyltransferase KAT7 isoform 3
NM_001199157.2 NP_001186086.1 histone acetyltransferase KAT7 isoform 4
NM_001199158.2 NP_001186087.1 histone acetyltransferase KAT7 isoform 5
NM_001346706.2 NP_001333635.1 histone acetyltransferase KAT7 isoform 6
NM_007067.5 NP_008998.1 histone acetyltransferase KAT7 isoform 1

KAT7 Protein Structure

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (183 - 212)

MOZ_SAS

MOZ_SAS: MOZ/SAS family (390 - 574)

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  • 611 a.a.
Protein Preferred Names Protein Names

histone acetyltransferase KAT7

K(lysine) acetyltransferase 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-134901 WM-3835 99.63% Unkown
HY-102058 WM-1119 Inhibitor 99.83% Unkown
HY-RS07083 KAT7 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KAT7 MGD MGI:2182799
Felis catus KAT7 VGNC VGNC:63026
Macaca mulatta KAT7 VGNC VGNC:99160
Bos taurus KAT7 VGNC VGNC:30403
Canis familiaris KAT7 VGNC VGNC:42214
Rattus norvegicus KAT7 RGD RGD:727966
Others KAT7 NCBI