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JADE1 - jade family PHD finger 1 Gene

Also Known as PHF17

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79960

About JADE1

Cytogenetic location: 4q28.2 Genomic coordinates (GRCh38): 4:128,809,700-128,875,224 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 13.1), ovary (RPKM 12.4) and 25 other tissues.

Summary

Enables transcription coactivator activity. Involved in histone acetylation and negative regulation of canonical Wnt signaling pathway. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including ciliary basal body; cytosol; and nuclear speck. Part of Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

JADE1 Products (8)

mRNA	Protein	Name
NM_001287437.2	NP_001274366.1	protein Jade-1 isoform 3
NM_001287439.2	NP_001274368.1	protein Jade-1 isoform 1
NM_001287440.2	NP_001274369.1	protein Jade-1 isoform 1
NM_001287441.2	NP_001274370.1	protein Jade-1 isoform 2
NM_001287442.1	NP_001274371.1	protein Jade-1 isoform 1
NM_001287443.1	NP_001274372.1	protein Jade-1 isoform 1
NM_024900.5	NP_079176.2	protein Jade-1 isoform 2
NM_199320.4	NP_955352.1	protein Jade-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to histone H3K14 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K12 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
NOT contributes to histone H4K16 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K5 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K8 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12169691	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23001567	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	23001567	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	22654112	GOA
involved in regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of DNA replication	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22144582	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	22144582	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	22654112	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12169691	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24739512	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	16387653	GOA
part of histone acetyltransferase complex	IPI IPI: Inferred from physical interaction	16387653	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	12169691	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16387653	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12169691	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23001567	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JADE1 Protein Structure

EPL1

PHD_2

zf-HC5HC2H_2

0
200
400
600
800
842 a.a.

Protein Preferred Names	Protein Names
protein Jade-1	PHD finger protein 17

JADE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	JADE1	Q6IE81	YJU2	Homo sapiens	Q9BW85	Validated Y2H	25416956
Intra	JADE1	Q6IE81	YJU2	Homo sapiens	Q9BW85	Y2H Array	25416956
Intra	JADE1	Q6IE81	NPHP4	Homo sapiens	O75161	IF	22654112
Intra	JADE1	Q6IE81	NPHP4	Homo sapiens	O75161	Anti Tag CoIP	22654112
Intra	JADE1	Q6IE81	KAT7	Homo sapiens	O95251	TAP	24981860
Intra	JADE1	Q6IE81	KAT7	Homo sapiens	O95251	Anti Tag CoIP	33961781
Intra	JADE1	Q6IE81	KAT7	Homo sapiens	O95251	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Atrophy Of Testis	Atrophic Testicle Atrophy Of Testicle Testicular Atrophy
Neuropathy, Hereditary Sensory And Autonomic, Type Iia	Hereditary Sensory And Autonomic Neuropathy Type 2 Hsan2 HSAN2A Morvan Disease Hereditary Sensory And Autonomic Neuropathy Type Ii Neurogenic Acroosteolysis Hsan Iia Hsn2a Hsn Iia Neuropathy, Progressive Sensory, Of Children Neuropathy, Congenital Sensory Neuropathy, Hereditary Sensory And Autonomic, Type Ii Hereditary Sensory And Autonomic Neuropathy Type 2a Hereditary Sensory And Autonomic Neuropathy Type Iia Hsanii Congenital Sensory Neuropathy Hsan Type Ii Morvan Syndrome Neuropathy, Hereditary Sensory And Autonomic, Type 2a Morvan'S Disease Neuropathy, Hereditary Sensory, Type Iia Acroosteolysis, Neurogenic Acroosteolysis, Giaccai Type Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive Hereditary Sensory Autonomic Neuropathy Type 2 Giaccai Type Acroosteolysis Hereditary Sensory Neuropathy Type 2 Hereditary Sensory Radicular Neuropathy, Recessive Form Hsan2b Hsan2c Hsan2d Hsn Type Ii Autosomal Recessive Sensory Radicular Neuropathy Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome Morvan Fibrillary Chorea Neuropathy, Hereditary Sensory And Autonomic, 2a Acroosteolysis Giaccai Type Hereditary Sensory Neuropathy Type Iia Hereditary Sensory Radicular Neuropathy Autosomal Recessive Progressive Sensory Neuropathy Of Children Neuropathy Congenital Sensory Charcot-Marie-Tooth Disease Neuropathy, Sensory And Autonomic, Hereditary, Type Iia Hereditary Sensory Autonomic Neuropathy, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii Sensory Neuropathy, Hereditary Neuropathy, Hereditary Sensory And Autonomic, Type Iib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07009	JADE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	JADE1	VGNC	VGNC:30358
Macaca mulatta	JADE1	VGNC	VGNC:73687
Rattus norvegicus	JADE1	RGD	RGD:1306920
Felis catus	JADE1	VGNC	VGNC:62995
Mus musculus	JADE1	MGD	MGI:1925835
Canis familiaris	JADE1	VGNC	VGNC:42169
Others	JADE1	NCBI