eIF4A3-IN-12

Cat. No.: HY-148446: FAQs
Data Sheet Handling Instructions

eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC₅₀s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis.

For research use only. We do not sell to patients.

eIF4A3-IN-12 Chemical Structure

CAS No. : 1402931-76-3

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Description	eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC₅₀s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis^[1].
Molecular Weight	496.94
Formula	C₂₇H₂₅ClO₇
CAS No.	1402931-76-3
SMILES	COC1=CC=C([[email protected]@]23OC4=CC(Cl)=CC(OC)=C4[[email protected]]2(O)[[email protected]@H]([[email protected]@H]([[email protected]]3C5=CC=CC=C5)C(OC)=O)O)C=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (279 KB) Handling Instructions (2659 KB)
References	[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

eIF4A3-IN-121402931-76-3Eukaryotic Initiation Factor (eIF)myc-LUCtub-LUCMBA-MB-231natural producttranslationInhibitorinhibitorinhibit

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eIF4A3-IN-12

Biological Activity

Purity & Documentation

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