1402931-76-3
Chemical Structure
eIF4A3-IN-12
- CAS No.: 1402931-76-3
- Formula:C27H25ClO7
- Molecular Weight:496.94
IUPAC Name: methyl (1R,2R,3S,3aR,8bS)-6-chloro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxylate
InChIKey: FAWAZAWGOJUXDV-PXIJUOARSA-N
SMILES: COC1=CC=C([C@@]23OC4=CC(Cl)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(OC)=O)O)C=C1
Biological Activity: eIF4A3-IN-12 (compound 62) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis[1].
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eIF4A3-IN-12 | eIF4A3-IN-12 (compound 62) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis. | |||||||||||||||||||||
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Keywords
