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Cat. No.: HY-157454

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Antiviral agent 48

Antiviral agent 48 (compound 9m) is a pan-antiviral agent. Antiviral agent 48 has anti-HEV activity and cytotoxicity (EC₉₀=30.6 nM; CC₅₀=13.8 nM).

For research use only. We do not sell to patients.

CAS No.: 3032868-59-7
Formula: C₂₇H₂₅BrO₇
Molecular Weight:541.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Antiviral agent 48 Chemical Structure

CAS No.: 3032868-59-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antiviral agent 48 (compound 9m) is a pan-antiviral agent. Antiviral agent 48 has anti-HEV activity and cytotoxicity (EC₉₀=30.6 nM; CC₅₀=13.8 nM)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	13.8 nM Compound: 9m	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 38127656]
HepG2	CC₅₀	420.9 nM Compound: 9m	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 38127656]
Huh-7	CC₅₀	>1000 nM Compound: 9m	Cytotoxicity against human Huh-7 cells after 48 hrs by MTT assay Cytotoxicity against human Huh-7 cells after 48 hrs by MTT assay	[PMID: 38127656]
Huh-7	CC₅₀	>1000 nM Compound: 9m	Cytotoxicity against human Huh-7 cells after 24 hrs by MTT assay Cytotoxicity against human Huh-7 cells after 24 hrs by MTT assay	[PMID: 38127656]
Vero C1008	CC₅₀	>1000 nM Compound: 9m	Cytotoxicity against african green monkey Vero E6 cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero E6 cells after 48 hrs by MTT assay	[PMID: 38127656]
Vero C1008	CC₅₀	>1000 nM Compound: 9m	Cytotoxicity against african green monkey Vero E6 cells after 24 hrs by MTT assay Cytotoxicity against african green monkey Vero E6 cells after 24 hrs by MTT assay	[PMID: 38127656]

Chemical Information

CAS No. 3032868-59-7
Molecular Weight 541.39
Formula C₂₇H₂₅BrO₇
SMILES

O[C@@H]1[C@@H]([C@H]([C@@]2(OC3=CC(Br)=CC(OC)=C3[C@@]21O)C4=CC=C(C=C4)OC)C5=CC=CC=C5)C(OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Catherine Victoria, et al. Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses. J Med Chem. 2024, 67, 1. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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