POLR2G - RNA polymerase II subunit G Gene

Also Known as RPB7; RPB19; hRPB19; hsRPB7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5436

About POLR2G

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,761,580-62,766,710 (from NCBI)

This gene has 8 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 35.1), brain (RPKM 26.4) and 25 other tissues.

Summary

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]

POLR2G Products (1)

mRNA Protein Name
NM_002696.3 NP_002687.1 DNA-directed RNA polymerase II subunit RPB7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9528765 GOA
Biological Process GO Annotation Evidence References Source
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9852112 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II, core complex IDA
IDA: Inferred from direct assay
9852112 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9852112 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR2G Protein Structure

SHS2_Rpb7-N

SHS2_Rpb7-N: SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 (11 - 77)

S1

S1: S1 RNA binding domain (78 - 157)

  • 0
  • 100
  • 172 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase II subunit RPB7

  • DNA directed RNA polymerase II 19 kda polypeptide

POLR2G Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POLR2G P62487 BCL2L15 Homo sapiens Q5TBC7
Validated Y2H
32296183
Intra
POLR2G P62487 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra
POLR2G P62487 DUSP29 Homo sapiens Q68J44
Validated Y2H
32296183
Intra
POLR2G P62487 TRAPPC2L Homo sapiens Q9UL33-2
Validated Y2H
32296183
Intra
POLR2G P62487 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra
POLR2G P62487 HOXC5 Homo sapiens Q00444
Validated Y2H
32296183
Intra
POLR2G P62487 C22orf15 Homo sapiens Q8WYQ4-2
Validated Y2H
32296183
Intra
POLR2G P62487 TRIM68 Homo sapiens Q6AZZ1
Validated Y2H
32296183
Intra
POLR2G P62487 CNTNAP2 Homo sapiens Q9UHC6
Validated Y2H
32296183
Intra
POLR2G P62487 KIF5B Homo sapiens P33176
Y2H Prey Pooling
32296183
Intra
POLR2G P62487 TSEN15 Homo sapiens Q8WW01
Validated Y2H
32296183
Intra
POLR2G P62487 PARVG Homo sapiens Q9HBI0
Validated Y2H
32296183
Intra
POLR2G P62487 UPRT Homo sapiens Q96BW1
Validated Y2H
32296183
Intra
POLR2G P62487 GPKOW Homo sapiens Q92917
Validated Y2H
32296183
Intra
POLR2G P62487 OSGIN1 Homo sapiens Q9UJX0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10848 POLR2G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21912 Polr2g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta POLR2G VGNC VGNC:76215
Mus musculus POLR2G MGD MGI:1914960
Felis catus POLR2G VGNC VGNC:68952
Bos taurus POLR2G VGNC VGNC:33141
Rattus norvegicus POLR2G RGD RGD:621284
Others POLR2G NCBI