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KIF5B - kinesin family member 5B Gene

Also Known as KNS; KINH; KNS1; UKHC; HEL-S-61

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3799

About KIF5B

Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:32,009,015-32,056,425 (from NCBI)

This gene has 2 transcripts (splice variants), 290 orthologues, 41 paralogues and is associated with 71 phenotypes. Ubiquitous expression in testis (RPKM 44.1), gall bladder (RPKM 42.8) and 25 other tissues.

Summary

Enables identical protein binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including lysosome localization; natural killer cell mediated cytotoxicity; and positive regulation of protein localization to plasma membrane. Located in centriolar satellite; cytosol; and vesicle. [provided by Alliance of Genome Resources, Apr 2022]

KIF5B Products (1)

mRNA	Protein	Name
NM_004521.3	NP_004512.1	kinesin-1 heavy chain

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17013387	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	28426968	GOA
enables microtubule motor activity	IDA IDA: Inferred from direct assay	28426968	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centrosome localization	IMP IMP: Inferred from mutant phenotype	20386726	GOA
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	22172677	GOA
involved in natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	24088571	GOA
involved in positive regulation of potassium ion transport	IDA IDA: Inferred from direct assay	19675065	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19675065	GOA
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	19675065	GOA
involved in vesicle transport along microtubule	IDA IDA: Inferred from direct assay	28426968	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in vesicle	IDA IDA: Inferred from direct assay	20682791	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF5B Protein Structure

Kinesin

0
200
400
600
800
963 a.a.

Protein Preferred Names	Protein Names
kinesin-1 heavy chain	conventional kinesin heavy chain

KIF5B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF5B	P33176	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	KIF5B	P33176	CDR2	Homo sapiens	Q01850	Validated Y2H	32296183
Intra	KIF5B	P33176	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	KIF5B	P33176	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	KIF5B	P33176	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	KIF5B	P33176	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	KIF5B	P33176	LBX1	Homo sapiens	P52954	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	LBX1	Homo sapiens	P52954	Validated Y2H	32296183
Intra	KIF5B	P33176	LBX1	Homo sapiens	P52954	Y2H Array	32296183
Intra	KIF5B	P33176	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	KIF5B	P33176	PRKAR2B	Homo sapiens	P31323	Y2H Array	32296183
Intra	KIF5B	P33176	PRKAR2B	Homo sapiens	P31323	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	KIF5B	P33176	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	KIF5B	P33176	YWHAZ	Homo sapiens	P63104	CoIP	15324660
Intra	KIF5B	P33176	POLR2G	Homo sapiens	P62487	Validated Y2H	32296183
Intra	KIF5B	P33176	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
Intra	KIF5B	P33176	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	KIF5B	P33176	YWHAB	Homo sapiens	P31946	CoIP	15324660
Intra	KIF5B	P33176	YWHAQ	Homo sapiens	P27348	CoIP	15324660
Intra	KIF5B	P33176	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
Intra	KIF5B	P33176	FHL2	Homo sapiens	Q14192	Y2H Array	32296183
Intra	KIF5B	P33176	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	KIF5B	P33176	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Cross	KIF5B	P33176	OPG164	vaccinia virus	P68619	Pull Down	21915095
Intra	KIF5B	P33176	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	KIF5B	P33176	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	KIF5B	P33176	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183
Intra	KIF5B	P33176	GCC1	Homo sapiens	Q96CN9	Y2H Prey Pooling	32296183
Intra	KIF5B	P33176	GCC1	Homo sapiens	Q96CN9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Histiocytosis	Chronic Histiocytosis X Hand Schuller Christian Disease Hand-Schüller-Christian Disease Histiocytic Syndrome Histiocytosis, Langerhans-Cell
Lung Combined Large Cell Neuroendocrine Carcinoma	Combined Large Cell Neuroendocrine Carcinoma Of Lung Pulmonary Combined Large Cell Neuroendocrine Carcinoma Combined Large Cell Lung Neuroendocrine Carcinoma
Occipital Lobe Neoplasm	Neoplasm Of Occipital Lobe Malignant Neoplasm Of Occipital Lobe Tumor Of Occipital Lobe
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Spastic Paraplegia 10, Autosomal Dominant	SPG10 Hereditary Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Type 10 Spastic Paraplegia 10 Spastic Paraplegia 10 With Or Without Peripheral Neuropathy Autosomal Dominant Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Spastic Paraplegia, Autosomal Dominant Paraplegia, Spastic, Autosomal Dominant, Type 10
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133551	WF-47-JS03	Inhibitor	99.63%	Unkown
HY-178061	APS03118	Inhibitor	/	Unkown
HY-146710	RET-IN-16	Inhibitor	/	Unkown
HY-170852	QZ2135	Degrader	/	Unkown
HY-170855A	YW-N-7 TFA	Degrader	/	Unkown
HY-178964	PROTAC RET Degrader 1	Degrader	/	Unkown
HY-RS07290	KIF5B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18287	Kif5b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24765	Kif5b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KIF5B	RGD	RGD:621559
Bos taurus	KIF5B	VGNC	VGNC:30606
Felis catus	KIF5B	VGNC	VGNC:67945
Mus musculus	KIF5B	MGD	MGI:1098268
Canis familiaris	KIF5B	VGNC	VGNC:42408
Macaca mulatta	KIF5B	VGNC	VGNC:74020
Others	KIF5B	NCBI