PRKAR2B - protein kinase cAMP-dependent type II regulatory subunit beta Gene

Also Known as PRKAR2; RII-BETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5577

About PRKAR2B

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:107,044,705-107,161,811 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 218 orthologues and 4 paralogues. Biased expression in fat (RPKM 215.5), adrenal (RPKM 38.6) and 7 other tissues.

Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]

PRKAR2B Products (1)

mRNA Protein Name
NM_002736.3 NP_002727.2 cAMP-dependent protein kinase type II-beta regulatory subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cAMP-dependent protein kinase inhibitor activity IDA
IDA: Inferred from direct assay
21812984 GOA
enables cAMP-dependent protein kinase regulator activity IDA
IDA: Inferred from direct assay
21812984 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17148597 GOA
enables protein kinase A catalytic subunit binding IPI
IPI: Inferred from physical interaction
21812984 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
21423175 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
21812984 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21423175 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21423175 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAR2B Protein Structure

RIIa

RIIa: Regulatory subunit of type II PKA R-subunit (8 - 44)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (174 - 259)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (295 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 418 a.a.
Protein Preferred Names Protein Names

cAMP-dependent protein kinase type II-beta regulatory subunit

  • H_RG363E19.2

PRKAR2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRKAR2B P31323 AKAP7 Homo sapiens O43687-2
Y2H Prey Pooling
32296183
Intra
PRKAR2B P31323 AKAP7 Homo sapiens O43687-2
Y2H Array
32296183
Intra
PRKAR2B P31323 AKAP7 Homo sapiens O43687-2
MAPPIT
32296183
Intra
PRKAR2B P31323 TAF12 Homo sapiens Q16514
Y2H Prey Pooling
32296183
Intra
PRKAR2B P31323 TAF12 Homo sapiens Q16514
Validated Y2H
32296183
Intra
PRKAR2B P31323 TAF12 Homo sapiens Q16514
Y2H Array
32296183
Intra
PRKAR2B P31323 AKAP14 Homo sapiens Q86UN6
Y2H Prey Pooling
32296183
Intra
PRKAR2B P31323 AKAP14 Homo sapiens Q86UN6
Validated Y2H
32296183
Intra
PRKAR2B P31323 AKAP14 Homo sapiens Q86UN6
Y2H Array
32296183
Intra
PRKAR2B P31323 KIF5B Homo sapiens P33176
Validated Y2H
32296183
Intra
PRKAR2B P31323 PRKACA Homo sapiens P17612
Anti Tag CoIP
33961781
Intra
PRKAR2B P31323 PRKACA Homo sapiens P17612
Anti Tag CoIP
25477193
Intra
PRKAR2B P31323 PRKACA Homo sapiens P17612
Y2H Prey Pooling
32296183
Intra
PRKAR2B P31323 PRKACA Homo sapiens P17612
Anti Tag CoIP
26496610
Intra
PRKAR2B P31323 PRKACA Homo sapiens P17612
FRET
25477193
Intra
PRKAR2B P31323 PRKACA Homo sapiens P17612
Y2H Array
32296183
Intra
PRKAR2B P31323 PRKACA Homo sapiens P17612
Affinity Chrom
25477193
Intra
PRKAR2B P31323 AKAP5 Homo sapiens P24588
Anti Tag CoIP
28514442
Intra
PRKAR2B P31323 AKAP5 Homo sapiens P24588
Y2H Array
32296183
Intra
PRKAR2B P31323 AKAP5 Homo sapiens P24588
Y2H Prey Pooling
32296183
Intra
PRKAR2B P31323 AKAP5 Homo sapiens P24588
Anti Tag CoIP
33961781
Intra
PRKAR2B P31323 C2orf88 Homo sapiens Q9BSF0
Y2H Array
32296183
Intra
PRKAR2B P31323 C2orf88 Homo sapiens Q9BSF0
Y2H Prey Pooling
32296183
Intra
PRKAR2B P31323 C2orf88 Homo sapiens Q9BSF0
Validated Y2H
32296183
Intra
PRKAR2B P31323 ECM1 Homo sapiens Q16610
Y2H Array
32296183
Intra
PRKAR2B P31323 ECM1 Homo sapiens Q16610
Validated Y2H
32296183
Intra
PRKAR2B P31323 ECM1 Homo sapiens Q16610
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

PRKAR2B Antibodies

Cat. No. Product Name Application Reactivity
HY-P80428 PKA 2 beta (regulatory subunit)Antibody (YA133) WB, IP, ICC/IF, IHC-P, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Primary Pigmented Nodular Adrenocortical Disease

  • Ppnad

  • Primary Pigmented Nodular Adrenal Dysplasia

  • Pigmented Nodular Adrenocortical Disease, Primary, 2

  • Pigmented Nodular Adrenocortical Disease, Primary, 1
Carney Complex Variant

  • Carney Complex

  • Carney Syndrome

  • Carney Complex, Type 1

  • Lamb Syndrome

  • Name Syndrome

  • Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome

  • Carney Complex - Trismus - Pseudocamptodactyly Syndrome

  • Carney Complex, Type 2

  • Car

  • Cnc1

  • Carney Myxoma-Endocrine Complex

  • Myxoma - Spotty Pigmentation - Endocrine Overactivity

  • Myxoma, Spotty Pigmentation, And Endocrine Overactivity

  • Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome

  • Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome

  • Carney Complex-Trismus-Pseudocamptodactyly Syndrome

  • CACOV
Fibrolamellar Carcinoma

  • Fibrolamellar Hepatocellular Carcinoma

  • Fhcc

  • Fibrolamellar Hepatocarcinoma

  • Hepatocellular Carcinoma, Fibrolamellar

  • Oncocytic Hepatocellular Tumor

  • Eosinophilic Glassy Cell Hepatoma

  • Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis

  • Fl-Hcc

  • Fibrolamellar Oncocytic Hepatoma

  • Hepatocellular Carcinoma With Increased Stromal Fibrosis

  • Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Spinocerebellar Ataxia, Autosomal Recessive 16

  • Autosomal Recessive Spinocerebellar Ataxia 16

  • SCAR16

  • Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency

  • Spinocerebellar Ataxia Autosomal Recessive Type 16

  • Spinocerebellar Ataxia, Autosomal Recessive, 16

  • Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
Acrodysostosis

  • Acrodysplasia

  • Arkless-Graham Syndrome

  • Maroteaux-Malamut Syndrome

  • Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome

  • Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Acth-Independent Macronodular Adrenal Hyperplasia

  • Acth-Independent Macronodular Adrenocortical Hyperplasia

  • Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia

  • Corticotropin-Independent Macronodular Adrenal Hyperplasia

  • Cushing Syndrome Due To Macronodular Adrenal Hyperplasia

  • AIMAH1

  • Aimah

  • Massive Macronodular Adrenocortical Disease

  • Mmad

  • Primary Macronodular Adrenal Hyperplasia

  • Cushing Syndrome, Adrenal, Due To Aimah

  • Primary Bilateral Macronodular Adrenal Hyperplasia

  • Acth-Independent Macronodular Adrenal Hyperplasia 1

  • Acth-Independent Cushing Syndrome

  • Adrenal Cushing Syndrome Due To Aimah

  • Acth-Independent Macronodular Adrenal Hyperplasia 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11115 PRKAR2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22021 Prkar2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28539 Prkar2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRKAR2B VGNC VGNC:69054
Canis familiaris PRKAR2B VGNC VGNC:44977
Rattus norvegicus PRKAR2B RGD RGD:3394
Macaca mulatta PRKAR2B VGNC VGNC:76408
Mus musculus PRKAR2B MGD MGI:97760
Bos taurus PRKAR2B VGNC VGNC:33326
Others PRKAR2B NCBI